Mean Platelet Volume in Pemphigus Vulgaris

Khalaf Kridin, Wesal Shihade, Shira Zelber-Sagi

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים


Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. The mean platelet volume (MPV) is an index of platelet activation reported to be influenced by inflammation. We investigated the MPV in patients with PV relative to controls. This case–control study included 160 patients with PV and 640 age- and sex-matched controls. The MPV, platelet count, and other inflammatory parameters were measured for all study participants. A significantly decreased MPV was observed in patients with PV compared with controls, 9.1 (1.5) fL versus 10.3 (1.4) fL, P <.001. A significant negative association between MPV and PV was demonstrated in multivariate analysis (odds ratio, 0.59; 95% confidence interval, 0.51-0.68, P <.0001). Patients having PV with laryngeal involvement had significantly lower MPVs than those without involvement of the larynx, 8.81 (1.5) fL versus 9.32 (1.4) fL, P =.032. Disease activity (before and after treatment) does not affect the MPV. Patients with PV showed decreased MPV values compared to healthy controls. The MPV may be a feasible diagnostic marker in patients with PV.

שפה מקוריתאנגלית אמריקאית
עמודים (מ-עד)303-307
מספר עמודים5
כתב עתAngiology
מספר גיליון4
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 אפר׳ 2018

הערה ביבליוגרפית

Publisher Copyright:
© 2017, © The Author(s) 2017.

ASJC Scopus subject areas

  • ???subjectarea.asjc.2700.2705???


להלן מוצגים תחומי המחקר של הפרסום 'Mean Platelet Volume in Pemphigus Vulgaris'. יחד הם יוצרים טביעת אצבע מחקרית ייחודית.

פורמט ציטוט ביבליוגרפי