Abstract
Background: The prognostic value of the first posttreatment whole body integrated positron emission tomography-computed tomography (PET/CT) scanning in patients with sinonasal/skull base malignancies is undetermined. Methods: We retrospectively reviewed the data of all patients that underwent surgery for sinonasal/skull base malignancies in 2000-2015. The results of the pretreatment and posttreatment PET/CT findings and the clinical course were retrieved. Results: Thirty-eight patients (average age 60.6 years, 20 males) were included. Sensitivity and specificity, positive predictive value, and negative predictive value of the first PET/CT scan for predicting persistent/recurrent disease were 85.7%, 87.5%, 80%, and 91.3%, respectively. Overall 5-year survival was significantly lower in the first posttreatment PET/CT-positive group (35%) compared to the PET/CT-negative group (93%) (P =.0008). Conclusion: Posttreatment PET/CT findings are highly prognostic in patients with sinonasal/skull base malignancies. Negative findings on the first posttreatment PET/CT scan predict a significantly better overall survival.
Original language | English |
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Pages (from-to) | 701-706 |
Number of pages | 6 |
Journal | Head and Neck |
Volume | 41 |
Issue number | 3 |
DOIs | |
State | Published - 1 Mar 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 Wiley Periodicals, Inc.
Keywords
- PET/CT
- prognosis
- sinonasal malignancy
- skull base
- survival
ASJC Scopus subject areas
- Otorhinolaryngology