Unpredictable chronic stress in juvenile or adult rats has opposite effects, respectively, promoting and impairing resilience

T. Ricon, E. Toth, M. Leshem, K. Braun, G. Richter-Levin

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the effects of early maternal deprivation (MD; age 714 days) alone or in combination with unpredictable chronic stress (UCS; MDUN; 2884 days) on anxiety and learning in 90 days old adult rats. We hypothesized that exposure to both stressors (MDUN) would be more detrimental than exposure to one or neither. Unexpectedly, adult rats from the MDUN group did not differ from control animals, whereas adult MD animals exhibited impaired avoidance learning. We next investigated the effect of juvenile-onset (3090 days) versus adult-onset (6090 days) stress on avoidance learning in adulthood (90 days). We found that adult-onset chronic stress impaired avoidance learning and memory whereas juvenile-onset stress did not. Thus, the results again indicate that juvenile exposure to UCS induces resilience rather than impairment.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalStress
Volume15
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Juvenile stress
  • Learning
  • Maternal deprivation
  • Rat
  • Two-way shuttle avoidance task
  • Unpredictable chronic stress

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Physiology
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Unpredictable chronic stress in juvenile or adult rats has opposite effects, respectively, promoting and impairing resilience'. Together they form a unique fingerprint.

Cite this