TY - JOUR
T1 - Understanding the impact of radical changes in diet and the gut microbiota on brain function and structure
T2 - rationale and design of the EMBRACE study
AU - EMRACE Study Team
AU - Ben-Porat, Tair
AU - Alberga, Angela
AU - Audet, Marie Claude
AU - Belleville, Sylvie
AU - Cohen, Tamara R.
AU - Garneau, Pierre Y.
AU - Lavoie, Kim L.
AU - Marion, Patrick
AU - Mellah, Samira
AU - Pescarus, Radu
AU - Rahme, Elham
AU - Santosa, Sylvia
AU - Studer, Anne Sophie
AU - Vuckovic, Dajana
AU - Woods, Robbie
AU - Yousefi, Reyhaneh
AU - Bacon, Simon L.
AU - Cohen, Tamara
N1 - Publisher Copyright:
© 2023 American Society for Metabolic and Bariatric Surgery
PY - 2023/9
Y1 - 2023/9
N2 - Background: Bariatric surgery leads to profound changes in gut microbiota and dietary patterns, both of which may interact to impact gut-brain communication. Though cognitive function improves postsurgery, there is a large variability in outcomes. How bariatric surgery-induced modifications in the gut microbiota and dietary patterns influence the variability in cognitive function is still unclear. Objectives: To elucidate the associations between bariatric surgery-induced changes in dietary and gut microbiota patterns with cognition and brain structure. Setting: University hospital. Methods: A total of 120 adult patients (≥30 years) scheduled to undergo a primary bariatric surgery along with 60 age-, sex-, and body mass index-matched patients on the surgery waitlist will undergo assessments 3-months presurgery and 6- and 12-month postsurgery (or an equivalent time for the waitlist group). Additionally, 60 age-and sex-matched nonbariatric surgery eligible individuals will complete the presurgical assessments only. Evaluations will include sociodemographic and health behavior questionnaires, physiological assessments (anthropometrics, blood-, urine-, and fecal-based measures), neuropsychological cognitive tests, and structural magnetic resonance imaging. Cluster analyses of the dietary and gut microbiota changes will define the various dietary patterns and microbiota profiles, then using repeated measures mixed models, their associations with global cognitive and structural brain alterations will be explored. Results: The coordinating study site (Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal, QC, Canada), provided the primary ethical approval (Research Ethics Board#: MP-32-2022-2412). Conclusions: The insights generated from this study can be used to develop individually-targeted neurodegenerative disease prevention strategies, as well as providing critical mechanistic information.
AB - Background: Bariatric surgery leads to profound changes in gut microbiota and dietary patterns, both of which may interact to impact gut-brain communication. Though cognitive function improves postsurgery, there is a large variability in outcomes. How bariatric surgery-induced modifications in the gut microbiota and dietary patterns influence the variability in cognitive function is still unclear. Objectives: To elucidate the associations between bariatric surgery-induced changes in dietary and gut microbiota patterns with cognition and brain structure. Setting: University hospital. Methods: A total of 120 adult patients (≥30 years) scheduled to undergo a primary bariatric surgery along with 60 age-, sex-, and body mass index-matched patients on the surgery waitlist will undergo assessments 3-months presurgery and 6- and 12-month postsurgery (or an equivalent time for the waitlist group). Additionally, 60 age-and sex-matched nonbariatric surgery eligible individuals will complete the presurgical assessments only. Evaluations will include sociodemographic and health behavior questionnaires, physiological assessments (anthropometrics, blood-, urine-, and fecal-based measures), neuropsychological cognitive tests, and structural magnetic resonance imaging. Cluster analyses of the dietary and gut microbiota changes will define the various dietary patterns and microbiota profiles, then using repeated measures mixed models, their associations with global cognitive and structural brain alterations will be explored. Results: The coordinating study site (Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal, QC, Canada), provided the primary ethical approval (Research Ethics Board#: MP-32-2022-2412). Conclusions: The insights generated from this study can be used to develop individually-targeted neurodegenerative disease prevention strategies, as well as providing critical mechanistic information.
KW - Bariatric surgery
KW - Brain structure
KW - Cognition
KW - Dietary patterns
KW - Microbiota
UR - http://www.scopus.com/inward/record.url?scp=85153202629&partnerID=8YFLogxK
U2 - 10.1016/j.soard.2023.02.022
DO - 10.1016/j.soard.2023.02.022
M3 - Article
C2 - 37088645
AN - SCOPUS:85153202629
SN - 1550-7289
VL - 19
SP - 1000
EP - 1012
JO - Surgery for Obesity and Related Diseases
JF - Surgery for Obesity and Related Diseases
IS - 9
ER -