Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: A preliminary study

Antonia S. New; Joel Gelernter; Yoram Yovell; Robert L. Trestman; David A. Nielsen; Jeremy Silverman; Vivian Mitropoulou; Larry J. Siever

doi:10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O

Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: A preliminary study

Antonia S. New, Joel Gelernter, Yoram Yovell, Robert L. Trestman, David A. Nielsen, Jeremy Silverman, Vivian Mitropoulou, Larry J. Siever

Research output: Contribution to journal › Article › peer-review

Abstract

To assess the relationship between two phenotypes in an extremely well- characterized population of personality disorder patients-impulsive aggression and prolactin response to fenfluramine-and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder. Impulsive aggression was assessed by using the Buss- Durkee Hostility Inventory (BDHI). Twenty-one male patients with the 'LL' genotype had higher BDHI scores than men with the 'U' or the 'UU' genotype. No relationship between genotype and prolactin response to fenfluramine was found. It was concluded that impulsive-aggressive behavior in male personality disorder patients may be associated with the TPH genotype.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	81
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O
State	Published - 7 Feb 1998
Externally published	Yes

Keywords

Genetics
Personality disorders
Polymorphism
Serotonin

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O

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New, A. S., Gelernter, J., Yovell, Y., Trestman, R. L., Nielsen, D. A., Silverman, J., Mitropoulou, V., & Siever, L. J. (1998). Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: A preliminary study. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 81(1), 13-17. https://doi.org/10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O

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abstract = "To assess the relationship between two phenotypes in an extremely well- characterized population of personality disorder patients-impulsive aggression and prolactin response to fenfluramine-and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder. Impulsive aggression was assessed by using the Buss- Durkee Hostility Inventory (BDHI). Twenty-one male patients with the 'LL' genotype had higher BDHI scores than men with the 'U' or the 'UU' genotype. No relationship between genotype and prolactin response to fenfluramine was found. It was concluded that impulsive-aggressive behavior in male personality disorder patients may be associated with the TPH genotype.",

keywords = "Genetics, Personality disorders, Polymorphism, Serotonin",

author = "New, {Antonia S.} and Joel Gelernter and Yoram Yovell and Trestman, {Robert L.} and Nielsen, {David A.} and Jeremy Silverman and Vivian Mitropoulou and Siever, {Larry J.}",

year = "1998",

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New, AS, Gelernter, J, Yovell, Y, Trestman, RL, Nielsen, DA, Silverman, J, Mitropoulou, V & Siever, LJ 1998, 'Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: A preliminary study', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 81, no. 1, pp. 13-17. https://doi.org/10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O

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AU - Mitropoulou, Vivian

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KW - Polymorphism

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Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: A preliminary study

Abstract

Keywords

ASJC Scopus subject areas

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