To assess the relationship between two phenotypes in an extremely well- characterized population of personality disorder patients-impulsive aggression and prolactin response to fenfluramine-and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder. Impulsive aggression was assessed by using the Buss- Durkee Hostility Inventory (BDHI). Twenty-one male patients with the 'LL' genotype had higher BDHI scores than men with the 'U' or the 'UU' genotype. No relationship between genotype and prolactin response to fenfluramine was found. It was concluded that impulsive-aggressive behavior in male personality disorder patients may be associated with the TPH genotype.
|Number of pages||5|
|Journal||American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics|
|State||Published - 7 Feb 1998|
- Personality disorders
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience