Summary: We present the software implementation of the tree scanning method to detect associations between genetic haplotypes and quantitative traits, utilizing the evolutionary history of the haplotypes, in samples of unrelated individuals.
Bibliographical noteFunding Information:
Part of this work was done at Variagenics, Inc (Cambridge, MA, USA). We thank Vincent Stanton, Jr, Daniel Chasman, Lakshman Subrahmanyan and Carsten Wiuf for the helpful discussions. Financial support from the Burroughs Wellcome Fund Innovation Award in Functional Genomics 100133, an NSF predoctoral fellowship award to T. J. M., and the National Institutes of Health grant GM65509 are gratefully acknowledged.
ASJC Scopus subject areas
- Computational Mathematics
- Molecular Biology
- Statistics and Probability
- Computer Science Applications
- Computational Theory and Mathematics