Treatment of T cell lymphoblastic lymphoma in children and adolescents: Israel society of pediatric hematology oncology retrospective study

Ofrat Beyar Katz, Ayelet Ben Barak, Gali Abrahami, Nira Arad, Yoav Burstein, Rina Dvir, Salvador Fischer, Joseph Kapelushnik, Haim Kaplinsky, Amos Toren, Shoshana Vilk-Revel, Michael Weintraub, Isaac Yaniv, Shai Linn, Boris Futerman, Myriam Weyl Ben-Arush

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Survival in T cell lymphoblastic lymphoma has improved over the past 30 years, largely due to treatment protocols derived from regimens designed for children with acute lymphoblastic leukemia. Objectives: To assess the outcome of the NHL-BFM-95 protocol in children and adolescents hospitalized during the period 1999-2006. Methods: We conducted a retrospective multi-institutional, non-randomized study of children and adolescents up to age 21 with T cell lymphoma admitted to pediatric departments in six hospitals in Israel, with regard to prevalence, clinical characteristics, pathological characteristics, prognostic factors, overall survival (OS) and event-free survival (EFS). All patients had a minimal follow-up of one year after diagnosis. The study was based on the NHL-BFM-95 protocol. results: At a median follow-up of 4 years (range 1-9 years), OS and EFS for all patients was 86.5% and 83.8%, respectively. OS was 86.7% and 83.3% for patients with stage III and stage IV, respectively, and EFS was 83.3% and 83.3%, respectively. EFS was 62.5% for Arab patients and 89.7% for Jewish patients (P = 0.014). Patients who did not express CD45 antigen showed superior survival (P = 0.028). Five patients (13.5%) relapsed, four of whom died of their disease. Death as a consequence of therapy toxicity was documented in one patient while on the re-induction protocol (protocol IIA). conclusions: Our study shows that OS and EFS for all patients was 86.5% and 83.8%, respectively.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalIsrael Medical Association Journal
Volume13
Issue number3
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Adolescents
  • Chemotherapy
  • Children
  • Lymphoblastic lymphoma
  • T cell

ASJC Scopus subject areas

  • Medicine (all)

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