Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory

Raphael Lamprecht, Yadin Dudai

Research output: Contribution to journalArticlepeer-review

Abstract

Local microinjection into rat amygdala of phosphorothioate modified oligodeoxynucleotides (ODNs) antisense to c-fos several hours before conditioned taste aversion (CTA) training impaired taste aversion memory tested 3-5 days after conditioning. In contrast, injection of the antisense ODNs several days before training, before testing, or into the basal ganglia, or injection of c-fos sense ODNs, had no effect on CTA memory. Inhibition of translation by local microinjection of anisomycin into the amygdala shortly before as well as during CTA training, but not several days before training or shortly before testing, also impaired CTA memory. We conclude that translation in general, and c-Fos translation in particular, in the amygdala during or immediately after CTA training is essential for encoding taste aversion memory.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalLearning and Memory
Volume3
Issue number1
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

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