Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework

Robert A. Greenes; Samson Tu; Aziz A. Boxwala; Mor Peleg; Edward H. Shortliffe

doi:10.1007/978-1-4613-0063-2_19

Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework

Robert A. Greenes, Samson Tu, Aziz A. Boxwala, Mor Peleg, Edward H. Shortliffe

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The knowledge contents of clinical practice guidelines and clinical trial protocols have much in common. A guideline specifies a recommended set of decisions and actions and the optimal pathways or sequences for carrying them out. Although often written in narrative form, guidelines should imply an underlying flowchart. Ideally such a flowchart is made explicit to resolve ambiguities and ensure that all potential pathways are fully specified.

Original language	English
Title of host publication	Cancer Informatics: Essential Technologies for Clinical Trials
Editors	John S. Silva, Marion J. Ball, Christopher G. Chute, Judith V. Douglas, Curtis P. Langlotz, Joyce C. Niland, William L. Scherlis
Place of Publication	New York, NY
Publisher	Springer New York LLC
Pages	212-228
Number of pages	17
ISBN (Print)	978-1-4613-0063-2
DOIs	https://doi.org/10.1007/978-1-4613-0063-2_19
State	Published - 2002
Externally published	Yes

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10.1007/978-1-4613-0063-2_19

https://doi.org/10.1007/978-1-4613-0063-2_19

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Greenes, R. A., Tu, S., Boxwala, A. A., Peleg, M., & Shortliffe, E. H. (2002). Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework. In J. S. Silva, M. J. Ball, C. G. Chute, J. V. Douglas, C. P. Langlotz, J. C. Niland, & W. L. Scherlis (Eds.), Cancer Informatics: Essential Technologies for Clinical Trials (pp. 212-228). Springer New York LLC. https://doi.org/10.1007/978-1-4613-0063-2_19

Greenes, Robert A. ; Tu, Samson ; Boxwala, Aziz A. et al. / Toward a Shared Representation of Clinical Trial Protocols : Application of the GLIF Guideline Modeling Framework. Cancer Informatics: Essential Technologies for Clinical Trials. editor / John S. Silva ; Marion J. Ball ; Christopher G. Chute ; Judith V. Douglas ; Curtis P. Langlotz ; Joyce C. Niland ; William L. Scherlis. New York, NY : Springer New York LLC, 2002. pp. 212-228

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title = "Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework",

abstract = "The knowledge contents of clinical practice guidelines and clinical trial protocols have much in common. A guideline specifies a recommended set of decisions and actions and the optimal pathways or sequences for carrying them out. Although often written in narrative form, guidelines should imply an underlying flowchart. Ideally such a flowchart is made explicit to resolve ambiguities and ensure that all potential pathways are fully specified.",

author = "Greenes, \{Robert A.\} and Samson Tu and Boxwala, \{Aziz A.\} and Mor Peleg and Shortliffe, \{Edward H.\}",

year = "2002",

doi = "10.1007/978-1-4613-0063-2\_19",

language = "English",

isbn = "978-1-4613-0063-2",

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editor = "Silva, \{John S.\} and Ball, \{Marion J.\} and Chute, \{Christopher G.\} and Douglas, \{Judith V.\} and Langlotz, \{Curtis P.\} and Niland, \{Joyce C.\} and Scherlis, \{William L.\}",

booktitle = "Cancer Informatics: Essential Technologies for Clinical Trials",

publisher = "Springer New York LLC",

}

Greenes, RA, Tu, S, Boxwala, AA, Peleg, M & Shortliffe, EH 2002, Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework. in JS Silva, MJ Ball, CG Chute, JV Douglas, CP Langlotz, JC Niland & WL Scherlis (eds), Cancer Informatics: Essential Technologies for Clinical Trials. Springer New York LLC, New York, NY, pp. 212-228. https://doi.org/10.1007/978-1-4613-0063-2_19

Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework. / Greenes, Robert A.; Tu, Samson; Boxwala, Aziz A. et al.
Cancer Informatics: Essential Technologies for Clinical Trials. ed. / John S. Silva; Marion J. Ball; Christopher G. Chute; Judith V. Douglas; Curtis P. Langlotz; Joyce C. Niland; William L. Scherlis. New York, NY: Springer New York LLC, 2002. p. 212-228.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Toward a Shared Representation of Clinical Trial Protocols

T2 - Application of the GLIF Guideline Modeling Framework

AU - Greenes, Robert A.

AU - Tu, Samson

AU - Boxwala, Aziz A.

AU - Peleg, Mor

AU - Shortliffe, Edward H.

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AB - The knowledge contents of clinical practice guidelines and clinical trial protocols have much in common. A guideline specifies a recommended set of decisions and actions and the optimal pathways or sequences for carrying them out. Although often written in narrative form, guidelines should imply an underlying flowchart. Ideally such a flowchart is made explicit to resolve ambiguities and ensure that all potential pathways are fully specified.

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DO - 10.1007/978-1-4613-0063-2_19

M3 - Chapter

SN - 978-1-4613-0063-2

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EP - 228

BT - Cancer Informatics: Essential Technologies for Clinical Trials

A2 - Silva, John S.

A2 - Ball, Marion J.

A2 - Chute, Christopher G.

A2 - Douglas, Judith V.

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A2 - Niland, Joyce C.

A2 - Scherlis, William L.

PB - Springer New York LLC

CY - New York, NY

ER -

Greenes RA, Tu S, Boxwala AA, Peleg M, Shortliffe EH. Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework. In Silva JS, Ball MJ, Chute CG, Douglas JV, Langlotz CP, Niland JC, Scherlis WL, editors, Cancer Informatics: Essential Technologies for Clinical Trials. New York, NY: Springer New York LLC. 2002. p. 212-228 doi: 10.1007/978-1-4613-0063-2_19

Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework

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