Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework

Robert A. Greenes, Samson Tu, Aziz A. Boxwala, Mor Peleg, Edward H. Shortliffe

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The knowledge contents of clinical practice guidelines and clinical trial protocols have much in common. A guideline specifies a recommended set of decisions and actions and the optimal pathways or sequences for carrying them out. Although often written in narrative form, guidelines should imply an underlying flowchart. Ideally such a flowchart is made explicit to resolve ambiguities and ensure that all potential pathways are fully specified.
Original languageEnglish
Title of host publicationCancer Informatics: Essential Technologies for Clinical Trials
EditorsJohn S. Silva, Marion J. Ball, Christopher G. Chute, Judith V. Douglas, Curtis P. Langlotz, Joyce C. Niland, William L. Scherlis
Place of PublicationNew York, NY
PublisherSpringer New York LLC
Number of pages17
ISBN (Print)978-1-4613-0063-2
StatePublished - 2002
Externally publishedYes

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