Tissue development and RNA control: "HOW" is it coordinated?

Talila Volk, David Israeli, Ronit Nir, Hila Toledano-Katchalski

Research output: Contribution to journalReview articlepeer-review


The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalTrends in Genetics
Issue number2
StatePublished - Feb 2008
Externally publishedYes

Bibliographical note

Funding Information:
We thank B. Shilo, Z. Paroush and S. Schwarzbaum for critical reading of the manuscript. The work in our laboratory is supported by a grant from the Israel Science Fund (ISF).

ASJC Scopus subject areas

  • Genetics


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