Tissue development and RNA control: "HOW" is it coordinated?

Talila Volk; David Israeli; Ronit Nir; Hila Toledano-Katchalski

doi:10.1016/j.tig.2007.11.009

Tissue development and RNA control: "HOW" is it coordinated?

Talila Volk, David Israeli, Ronit Nir, Hila Toledano-Katchalski

Research output: Contribution to journal › Review article › peer-review

Abstract

The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.

Original language	English
Pages (from-to)	94-101
Number of pages	8
Journal	Trends in Genetics
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.tig.2007.11.009
State	Published - Feb 2008
Externally published	Yes

Bibliographical note

Funding Information:
We thank B. Shilo, Z. Paroush and S. Schwarzbaum for critical reading of the manuscript. The work in our laboratory is supported by a grant from the Israel Science Fund (ISF).

ASJC Scopus subject areas

Genetics

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10.1016/j.tig.2007.11.009

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abstract = "The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.",

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AU - Volk, Talila

AU - Israeli, David

AU - Nir, Ronit

AU - Toledano-Katchalski, Hila

N1 - Funding Information: We thank B. Shilo, Z. Paroush and S. Schwarzbaum for critical reading of the manuscript. The work in our laboratory is supported by a grant from the Israel Science Fund (ISF).

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AB - The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.

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Tissue development and RNA control: "HOW" is it coordinated?

Abstract

Bibliographical note

ASJC Scopus subject areas

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