The self, neuroscience and psychosis study: Testing a neurophenomenological model of the onset of psychosis

Marija Krcmar; Cassandra M.J. Wannan; Suzie Lavoie; Kelly Allott; Christopher G. Davey; Hok Pan Yuen; Thomas Whitford; Melanie Formica; Sarah Youn; Jashmina Shetty; Rebecca Beedham; Victoria Rayner; Graham Murray; Andrea Polari; Łukasz Gawęda; Dan Koren; Louis Sass; Josef Parnas; Andreas R. Rasmussen; Patrick McGorry; Jessica A. Hartmann; Barnaby Nelson

doi:10.1111/eip.13448

The self, neuroscience and psychosis study: Testing a neurophenomenological model of the onset of psychosis

Marija Krcmar, Cassandra M.J. Wannan, Suzie Lavoie, Kelly Allott, Christopher G. Davey, Hok Pan Yuen, Thomas Whitford, Melanie Formica, Sarah Youn, Jashmina Shetty, Rebecca Beedham, Victoria Rayner, Graham Murray, Andrea Polari, Łukasz Gawęda, Dan Koren, Louis Sass, Josef Parnas, Andreas R. Rasmussen, Patrick McGorryJessica A. Hartmann, Barnaby Nelson

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Basic self disturbance is a putative core vulnerability marker of schizophrenia spectrum disorders. The primary aims of the Self, Neuroscience and Psychosis (SNAP) study are to: (1) empirically test a previously described neurophenomenological self-disturbance model of psychosis by examining the relationship between specific clinical, neurocognitive, and neurophysiological variables in UHR patients, and (2) develop a prediction model using these neurophenomenological disturbances for persistence or deterioration of UHR symptoms at 12-month follow-up. Methods: SNAP is a longitudinal observational study. Participants include 400 UHR individuals, 100 clinical controls with no attenuated psychotic symptoms, and 50 healthy controls. All participants complete baseline clinical and neurocognitive assessments and electroencephalography. The UHR sample are followed up for a total of 24 months, with clinical assessment completed every 6 months. Results: This paper presents the protocol of the SNAP study, including background rationale, aims and hypotheses, design, and assessment procedures. Conclusions: The SNAP study will test whether neurophenomenological disturbances associated with basic self-disturbance predict persistence or intensification of UHR symptomatology over a 2-year follow up period, and how specific these disturbances are to a clinical population with attenuated psychotic symptoms. This may ultimately inform clinical care and pathoaetiological models of psychosis.

Original language	English
Journal	Early Intervention in Psychiatry
Early online date	2 Jul 2023
DOIs	https://doi.org/10.1111/eip.13448
State	E-pub ahead of print - 2 Jul 2023

Bibliographical note

Funding Information:
This study is supported by a Wellcome Trust Flagship Award (UNS89574). BN was supported by an NHMRC Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship. KA is supported by a Dame Kate Campbell Fellowship from the University of Melbourne. AR was supported by an Independent Research Fund Denmark. Open access publishing facilitated by The University of Melbourne, as part of the Wiley ‐ The University of Melbourne agreement via the Council of Australian University Librarians.

Publisher Copyright:
© 2023 The Authors. Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.

Keywords

neurocognition
neurophysiology
phenomenology
protocol
self-disturbance
ultra-high risk

ASJC Scopus subject areas

Psychiatric Mental Health
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/eip.13448

Cite this

Krcmar, M., Wannan, C. M. J., Lavoie, S., Allott, K., Davey, C. G., Yuen, H. P., Whitford, T., Formica, M., Youn, S., Shetty, J., Beedham, R., Rayner, V., Murray, G., Polari, A., Gawęda, Ł., Koren, D., Sass, L., Parnas, J., Rasmussen, A. R., ... Nelson, B. (2023). The self, neuroscience and psychosis study: Testing a neurophenomenological model of the onset of psychosis. Early Intervention in Psychiatry. Advance online publication. https://doi.org/10.1111/eip.13448

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abstract = "Aim: Basic self disturbance is a putative core vulnerability marker of schizophrenia spectrum disorders. The primary aims of the Self, Neuroscience and Psychosis (SNAP) study are to: (1) empirically test a previously described neurophenomenological self-disturbance model of psychosis by examining the relationship between specific clinical, neurocognitive, and neurophysiological variables in UHR patients, and (2) develop a prediction model using these neurophenomenological disturbances for persistence or deterioration of UHR symptoms at 12-month follow-up. Methods: SNAP is a longitudinal observational study. Participants include 400 UHR individuals, 100 clinical controls with no attenuated psychotic symptoms, and 50 healthy controls. All participants complete baseline clinical and neurocognitive assessments and electroencephalography. The UHR sample are followed up for a total of 24 months, with clinical assessment completed every 6 months. Results: This paper presents the protocol of the SNAP study, including background rationale, aims and hypotheses, design, and assessment procedures. Conclusions: The SNAP study will test whether neurophenomenological disturbances associated with basic self-disturbance predict persistence or intensification of UHR symptomatology over a 2-year follow up period, and how specific these disturbances are to a clinical population with attenuated psychotic symptoms. This may ultimately inform clinical care and pathoaetiological models of psychosis.",

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author = "Marija Krcmar and Wannan, {Cassandra M.J.} and Suzie Lavoie and Kelly Allott and Davey, {Christopher G.} and Yuen, {Hok Pan} and Thomas Whitford and Melanie Formica and Sarah Youn and Jashmina Shetty and Rebecca Beedham and Victoria Rayner and Graham Murray and Andrea Polari and {\L}ukasz Gaw{\c e}da and Dan Koren and Louis Sass and Josef Parnas and Rasmussen, {Andreas R.} and Patrick McGorry and Hartmann, {Jessica A.} and Barnaby Nelson",

note = "Funding Information: This study is supported by a Wellcome Trust Flagship Award (UNS89574). BN was supported by an NHMRC Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship. KA is supported by a Dame Kate Campbell Fellowship from the University of Melbourne. AR was supported by an Independent Research Fund Denmark. Open access publishing facilitated by The University of Melbourne, as part of the Wiley ‐ The University of Melbourne agreement via the Council of Australian University Librarians. Publisher Copyright: {\textcopyright} 2023 The Authors. Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.",

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Krcmar, M, Wannan, CMJ, Lavoie, S, Allott, K, Davey, CG, Yuen, HP, Whitford, T, Formica, M, Youn, S, Shetty, J, Beedham, R, Rayner, V, Murray, G, Polari, A, Gawęda, Ł, Koren, D, Sass, L, Parnas, J, Rasmussen, AR, McGorry, P, Hartmann, JA & Nelson, B 2023, 'The self, neuroscience and psychosis study: Testing a neurophenomenological model of the onset of psychosis', Early Intervention in Psychiatry. https://doi.org/10.1111/eip.13448

TY - JOUR

T1 - The self, neuroscience and psychosis study

T2 - Testing a neurophenomenological model of the onset of psychosis

AU - Krcmar, Marija

AU - Wannan, Cassandra M.J.

AU - Lavoie, Suzie

AU - Allott, Kelly

AU - Davey, Christopher G.

AU - Yuen, Hok Pan

AU - Whitford, Thomas

AU - Formica, Melanie

AU - Youn, Sarah

AU - Shetty, Jashmina

AU - Beedham, Rebecca

AU - Rayner, Victoria

AU - Murray, Graham

AU - Polari, Andrea

AU - Gawęda, Łukasz

AU - Koren, Dan

AU - Sass, Louis

AU - Parnas, Josef

AU - Rasmussen, Andreas R.

AU - McGorry, Patrick

AU - Hartmann, Jessica A.

AU - Nelson, Barnaby

N1 - Funding Information: This study is supported by a Wellcome Trust Flagship Award (UNS89574). BN was supported by an NHMRC Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship. KA is supported by a Dame Kate Campbell Fellowship from the University of Melbourne. AR was supported by an Independent Research Fund Denmark. Open access publishing facilitated by The University of Melbourne, as part of the Wiley ‐ The University of Melbourne agreement via the Council of Australian University Librarians. Publisher Copyright: © 2023 The Authors. Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.

PY - 2023/7/2

Y1 - 2023/7/2

N2 - Aim: Basic self disturbance is a putative core vulnerability marker of schizophrenia spectrum disorders. The primary aims of the Self, Neuroscience and Psychosis (SNAP) study are to: (1) empirically test a previously described neurophenomenological self-disturbance model of psychosis by examining the relationship between specific clinical, neurocognitive, and neurophysiological variables in UHR patients, and (2) develop a prediction model using these neurophenomenological disturbances for persistence or deterioration of UHR symptoms at 12-month follow-up. Methods: SNAP is a longitudinal observational study. Participants include 400 UHR individuals, 100 clinical controls with no attenuated psychotic symptoms, and 50 healthy controls. All participants complete baseline clinical and neurocognitive assessments and electroencephalography. The UHR sample are followed up for a total of 24 months, with clinical assessment completed every 6 months. Results: This paper presents the protocol of the SNAP study, including background rationale, aims and hypotheses, design, and assessment procedures. Conclusions: The SNAP study will test whether neurophenomenological disturbances associated with basic self-disturbance predict persistence or intensification of UHR symptomatology over a 2-year follow up period, and how specific these disturbances are to a clinical population with attenuated psychotic symptoms. This may ultimately inform clinical care and pathoaetiological models of psychosis.

AB - Aim: Basic self disturbance is a putative core vulnerability marker of schizophrenia spectrum disorders. The primary aims of the Self, Neuroscience and Psychosis (SNAP) study are to: (1) empirically test a previously described neurophenomenological self-disturbance model of psychosis by examining the relationship between specific clinical, neurocognitive, and neurophysiological variables in UHR patients, and (2) develop a prediction model using these neurophenomenological disturbances for persistence or deterioration of UHR symptoms at 12-month follow-up. Methods: SNAP is a longitudinal observational study. Participants include 400 UHR individuals, 100 clinical controls with no attenuated psychotic symptoms, and 50 healthy controls. All participants complete baseline clinical and neurocognitive assessments and electroencephalography. The UHR sample are followed up for a total of 24 months, with clinical assessment completed every 6 months. Results: This paper presents the protocol of the SNAP study, including background rationale, aims and hypotheses, design, and assessment procedures. Conclusions: The SNAP study will test whether neurophenomenological disturbances associated with basic self-disturbance predict persistence or intensification of UHR symptomatology over a 2-year follow up period, and how specific these disturbances are to a clinical population with attenuated psychotic symptoms. This may ultimately inform clinical care and pathoaetiological models of psychosis.

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KW - neurophysiology

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KW - protocol

KW - self-disturbance

KW - ultra-high risk

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DO - 10.1111/eip.13448

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SN - 1751-7885

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

ER -

The self, neuroscience and psychosis study: Testing a neurophenomenological model of the onset of psychosis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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