The role of the subthalamic nucleus in 'compulsive' behavior in rats

Christine Winter, Shira Flash, Oded Klavir, Julia Klein, Reinhard Sohr, Daphna Joel

Research output: Contribution to journalArticlepeer-review


Different lines of evidence point to dysfunction of basal ganglia-thalamocortical circuits in obsessive-compulsive disorder (OCD). It has been hypothesized that the circuits' dysfunction in OCD may be characterized by a relative under-activity of the indirect compared with the direct pathway within these circuits. The present study tested whether lesions of the subthalamic nucleus (STN), a major node of the indirect pathway, would affect compulsive behavior, using the signal attenuation rat model of OCD. In this model, compulsive lever-pressing is induced by the attenuation of an external signal of reward delivery; an attenuation that is hypothesized to simulate the deficient response feedback suggested to underlie obsessions and compulsions in patients with OCD. Rats sustaining lesions to the STN showed a selective increase in compulsive lever-pressing compared with sham-operated rats. A post mortem biochemical analysis revealed a decrease in serotonin content in the prelimbic and infralimbic cortices, caudate-putamen (but not nucleus accumbens), globus pallidus and substantia nigra-ventral tegmental area, as well as a decrease in dopamine content in the caudate-putamen in STN-lesioned compared with sham rats. A comparison to recent findings that lesions to the orbitofrontal cortex, which also result in a selective increase in compulsive lever-pressing, lead to a decrease in serotonin and dopamine content in the caudate-putamen suggests that there may be a final common pathway by which different brain pathologies may lead to a pro-compulsive state.

Original languageEnglish
Pages (from-to)1902-1911
Number of pages10
JournalEuropean Journal of Neuroscience
Issue number8
StatePublished - Apr 2008
Externally publishedYes


  • Dopamine
  • Obsessive-compulsive disorder (OCD)
  • Post-training signal attenuation
  • Serotonin
  • Striatum

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'The role of the subthalamic nucleus in 'compulsive' behavior in rats'. Together they form a unique fingerprint.

Cite this