The role of oxytocin in modulating interpersonal space: A pharmacological fMRI study

Daniela Cohen, Anat Perry, Gadi Gilam, Naama Mayseless, Tal Gonen, Talma Hendler, Simone G. Shamay-Tsoory

Research output: Contribution to journalArticlepeer-review

Abstract

Interpersonal space is a nonverbal indicator of affiliation and closeness. In this study we investigated the effects of oxytocin (OT), a neuropeptide known for its social role in humans, on interpersonal space. In a double blind placebo controlled study we measured the effect of intranasal OT on the personal distance preferences of different familiar (friend) and unfamiliar (stranger) protagonists. Behavioral results showed that participants preferred to be closer to a friend than to a stranger. Intranasal OT was associated with an overall distancing effect, but this effect was significant for the stranger and not for the friend. The imaging results showed interactions between treatment (OT, placebo) and protagonist (friend, stranger) in regions that mediate social behavior including the dorsomedial prefrontal cortex (dmPFC), a region associated with the mentalizing system. Specifically, OT increased activity in the dmPFC when a friend approached the participants but not when a stranger approached. The results indicate that the effect of OT on interpersonal space greatly depends on the participant's relationship with the protagonist. This supports the social salience theory, according to which OT increases the salience of social cues depending on the context.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalPsychoneuroendocrinology
Volume76
DOIs
StatePublished - 1 Feb 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

  • Dorsomedial prefrontal cortex
  • Interpersonal space
  • Mentalizing
  • Oxytocin

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint

Dive into the research topics of 'The role of oxytocin in modulating interpersonal space: A pharmacological fMRI study'. Together they form a unique fingerprint.

Cite this