The role of eEF2 pathway in learning and synaptic plasticity

Elham Taha, Iness Gildish, Shunit Gal-Ben-Ari, Kobi Rosenblum

Research output: Contribution to journalArticlepeer-review


One of the hallmarks of learning processes in any species studied so far is that they require intact protein synthesis machinery in order to consolidate memories. Interestingly, synaptic plasticity and consolidation processes share similar molecular mechanisms. In recent years, different laboratories have been studying regulation of translation machinery as a molecular entity underlying the consolidation process. Protein synthesis consists of three phases: initiation, elongation, and termination. The initiation step is considered the rate limiting step of protein synthesis. However, there is growing evidence that critical regulation of protein synthesis occurs at the elongation phase as well. Here, we focus on the eukaryotic elongation factor 2 (eEF2) pathway as a major regulator of protein synthesis, synaptic plasticity and memory consolidation.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalNeurobiology of Learning and Memory
StatePublished - Oct 2013

Bibliographical note

Funding Information:
This work was supported by ERANET system biology (SYNSYS), ISF (1003/12), and European Union Seventh Framework Program EUROSPIN (Contract HEALTH-F2-2009-241498), and the German-Israeli Foundation DIP (RO3971/1-1) grants to K.R.


  • Elongation
  • Learning
  • Memory
  • Protein synthesis
  • Protein translation
  • Synaptic plasticity

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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