The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis

Jeny Shklover, Flonia Levy-Adam, Estee Kurant

Research output: Contribution to journalArticlepeer-review


Eiger, the sole Drosophila TNF-alpha homolog, causes ectopic apoptosis through JNK pathway activation. Yet, its role in developmental apoptosis remains unclear. eiger mutant flies are viable and fertile but display compromised elimination of oncogenic cells and extracellular bacteria. Here we show that Eiger, specifically expressed in embryonic neurons and glia, is not involved in developmental neuronal apoptosis or in apoptotic cell clearance. Instead, we provide evidence that Eiger is required for damage-induced apoptosis in the embryonic CNS through regulation of the pro-apoptotic gene hid independently of the JNK pathway. Our study thus reveals a new requirement for Eiger in eliminating damaged cells during development.

Original languageEnglish
Pages (from-to)871-879
Number of pages9
JournalFEBS Letters
Issue number8
StatePublished - 2 Apr 2015
Externally publishedYes

Bibliographical note

Funding Information:
We would like to thank B. Jones, D. Bohmann, G.W. Davis, E. Arama, H. Steller, M. Miura, O. Schuldiner, A. Salzberg, Hybridoma bank and the Bloomington Stock Center for generously providing fly strains and antibodies. We thank Dr. Alexander Nevelsky and Egor Borzov from Department of Oncology, Rambam Medical Center (RMC) for their assistance in the X-ray experiments. We thank Z. Paroush and T. Schultheiss for comments on the manuscript and the Kurant laboratory members for constructive criticism and support. We also thank E. Suss-Toby at the Interdepartmental Bioimaging facility for excellent technical support. We gratefully acknowledge financial support from Rappaport Institute and from Allen and Jewell Prince Center for Neurodegenerative Disorders of the Brain.

Publisher Copyright:
© 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license.


  • Apoptosis
  • CNS
  • Drosophila
  • Eiger
  • Embryo
  • hid

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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