The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

Johnny King L. Lau; Glyn W. Humphreys; Hassan Douis; Alex Balani; Wai Ling Bickerton; Pia Rotshtein

doi:10.1016/j.nicl.2015.01.015

The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

Johnny King L. Lau, Glyn W. Humphreys, Hassan Douis, Alex Balani, Wai Ling Bickerton, Pia Rotshtein

Research output: Contribution to journal › Article › peer-review

Abstract

We report a lesion-symptom mapping analysis of visual speech production deficits in a large group (280) of stroke patients at the sub-acute stage (<120 days post-stroke). Performance on object naming was evaluated alongside three other tests of visual speech production, namely sentence production to a picture, sentence reading and nonword reading. A principal component analysis was performed on all these tests' scores and revealed a 'shared' component that loaded across all the visual speech production tasks and a 'unique' component that isolated object naming from the other three tasks. Regions for the shared component were observed in the left fronto-temporal cortices, fusiform gyrus and bilateral visual cortices. Lesions in these regions linked to both poor object naming and impairment in general visual-speech production. On the other hand, the unique naming component was potentially associated with the bilateral anterior temporal poles, hippocampus and cerebellar areas. This is in line with the models proposing that object naming relies on a left-lateralised language dominant system that interacts with a bilateral anterior temporal network. Neuropsychological deficits in object naming can reflect both the increased demands specific to the task and the more general difficulties in language processing.

Original language	English
Pages (from-to)	463-475
Number of pages	13
Journal	NeuroImage: Clinical
Volume	7
DOIs	https://doi.org/10.1016/j.nicl.2015.01.015
State	Published - 2015
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Stroke Association ( TSA 2010/2 ) and the Oxford NIHR Cognitive Health Clinical Research Facility ( RP-DG-0610-10046 ). The authors are grateful to all the participants who took part in the research and the UK West Midlands Stroke Research Network for their generous support and advice in patient recruitment. We thank the support of the local principal investigators and collaborators who facilitated data collection in the respective research sites and also Dr Magdelena Chechlacz of University of Oxford for providing statistical advice and assistance.

Publisher Copyright:
© 2014 Published by Elsevier Ltd.

Keywords

BCoS
CT
Nonword reading
Picture description
Picture naming
Principal component analysis
Sentence production
Sentence reading
Speech production
Stroke
VBM

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology
Cognitive Neuroscience

Access to Document

10.1016/j.nicl.2015.01.015

Cite this

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title = "The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study",

abstract = "We report a lesion-symptom mapping analysis of visual speech production deficits in a large group (280) of stroke patients at the sub-acute stage (<120 days post-stroke). Performance on object naming was evaluated alongside three other tests of visual speech production, namely sentence production to a picture, sentence reading and nonword reading. A principal component analysis was performed on all these tests' scores and revealed a 'shared' component that loaded across all the visual speech production tasks and a 'unique' component that isolated object naming from the other three tasks. Regions for the shared component were observed in the left fronto-temporal cortices, fusiform gyrus and bilateral visual cortices. Lesions in these regions linked to both poor object naming and impairment in general visual-speech production. On the other hand, the unique naming component was potentially associated with the bilateral anterior temporal poles, hippocampus and cerebellar areas. This is in line with the models proposing that object naming relies on a left-lateralised language dominant system that interacts with a bilateral anterior temporal network. Neuropsychological deficits in object naming can reflect both the increased demands specific to the task and the more general difficulties in language processing.",

keywords = "BCoS, CT, Nonword reading, Picture description, Picture naming, Principal component analysis, Sentence production, Sentence reading, Speech production, Stroke, VBM",

author = "Lau, {Johnny King L.} and Humphreys, {Glyn W.} and Hassan Douis and Alex Balani and Bickerton, {Wai Ling} and Pia Rotshtein",

note = "Funding Information: This work was supported by the Stroke Association ( TSA 2010/2 ) and the Oxford NIHR Cognitive Health Clinical Research Facility ( RP-DG-0610-10046 ). The authors are grateful to all the participants who took part in the research and the UK West Midlands Stroke Research Network for their generous support and advice in patient recruitment. We thank the support of the local principal investigators and collaborators who facilitated data collection in the respective research sites and also Dr Magdelena Chechlacz of University of Oxford for providing statistical advice and assistance. Publisher Copyright: {\textcopyright} 2014 Published by Elsevier Ltd.",

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AU - Humphreys, Glyn W.

AU - Douis, Hassan

AU - Balani, Alex

AU - Bickerton, Wai Ling

AU - Rotshtein, Pia

N1 - Funding Information: This work was supported by the Stroke Association ( TSA 2010/2 ) and the Oxford NIHR Cognitive Health Clinical Research Facility ( RP-DG-0610-10046 ). The authors are grateful to all the participants who took part in the research and the UK West Midlands Stroke Research Network for their generous support and advice in patient recruitment. We thank the support of the local principal investigators and collaborators who facilitated data collection in the respective research sites and also Dr Magdelena Chechlacz of University of Oxford for providing statistical advice and assistance. Publisher Copyright: © 2014 Published by Elsevier Ltd.

PY - 2015

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N2 - We report a lesion-symptom mapping analysis of visual speech production deficits in a large group (280) of stroke patients at the sub-acute stage (<120 days post-stroke). Performance on object naming was evaluated alongside three other tests of visual speech production, namely sentence production to a picture, sentence reading and nonword reading. A principal component analysis was performed on all these tests' scores and revealed a 'shared' component that loaded across all the visual speech production tasks and a 'unique' component that isolated object naming from the other three tasks. Regions for the shared component were observed in the left fronto-temporal cortices, fusiform gyrus and bilateral visual cortices. Lesions in these regions linked to both poor object naming and impairment in general visual-speech production. On the other hand, the unique naming component was potentially associated with the bilateral anterior temporal poles, hippocampus and cerebellar areas. This is in line with the models proposing that object naming relies on a left-lateralised language dominant system that interacts with a bilateral anterior temporal network. Neuropsychological deficits in object naming can reflect both the increased demands specific to the task and the more general difficulties in language processing.

AB - We report a lesion-symptom mapping analysis of visual speech production deficits in a large group (280) of stroke patients at the sub-acute stage (<120 days post-stroke). Performance on object naming was evaluated alongside three other tests of visual speech production, namely sentence production to a picture, sentence reading and nonword reading. A principal component analysis was performed on all these tests' scores and revealed a 'shared' component that loaded across all the visual speech production tasks and a 'unique' component that isolated object naming from the other three tasks. Regions for the shared component were observed in the left fronto-temporal cortices, fusiform gyrus and bilateral visual cortices. Lesions in these regions linked to both poor object naming and impairment in general visual-speech production. On the other hand, the unique naming component was potentially associated with the bilateral anterior temporal poles, hippocampus and cerebellar areas. This is in line with the models proposing that object naming relies on a left-lateralised language dominant system that interacts with a bilateral anterior temporal network. Neuropsychological deficits in object naming can reflect both the increased demands specific to the task and the more general difficulties in language processing.

KW - BCoS

KW - CT

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KW - Picture description

KW - Picture naming

KW - Principal component analysis

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KW - Sentence reading

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ER -

The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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