The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample

Vera A. Barata; Suzie Lavoie; Łukasz Gawęda; Emily Li; Louis A. Sass; Danny Koren; Patrick D. McGorry; Bradley N. Jack; Josef Parnas; Andrea Polari; Kelly Allott; Jessica A. Hartmann; Marija Krcmar; Andreas R. Rasmussen; Thomas J. Whitford; Cassandra M.J. Wannan; Barnaby Nelson

doi:10.1177/10398562251346619

The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample

Vera A. Barata
, Suzie Lavoie
, Łukasz Gawęda
, Emily Li
, Louis A. Sass
, Danny Koren
, Patrick D. McGorry
, Bradley N. Jack
, Josef Parnas
, Andrea Polari
, Kelly Allott
, Jessica A. Hartmann
, Marija Krcmar
, Andreas R. Rasmussen
, Thomas J. Whitford
, Cassandra M.J. Wannan
, Barnaby Nelson

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: We previously proposed a neurophenomenological model of schizophrenia, linking basic self-disturbance with neural deficits of source monitoring and aberrant salience. Baseline comparisons in ultra-high risk (UHR) and first-episode psychosis (FEP) samples indicated a relationship between basic self-disturbance and source monitoring deficits, but not aberrant salience. The current paper reports on the 12-month follow-up results in the UHR group (n = 43), focusing on the association between baseline variables and clinical outcomes. Methods: One-way ANOVA compared UHR-remitters (n = 18), UHR-persistent/transitioned to psychosis cases (n = 25) and FEP (n = 38) groups on baseline clinical and neuro-measures. Logistic regression assessed the baseline variables’ predictive power for UHR outcomes. Results: Higher baseline self-disturbance scores (EASE total) were found in the UHR persistence/transition and FEP groups compared to the UHR-remission group, and predicted worse UHR clinical outcomes. Source monitoring deficits were higher in FEP individuals compared to those with UHR persistence/transition. Conclusion: High levels of basic self-disturbance may be a useful predictor marker of poor prognosis in UHR patients.

Original language	English
Pages (from-to)	736-741
Number of pages	6
Journal	Australasian Psychiatry
Volume	33
Issue number	4
Early online date	4 Jun 2025
DOIs	https://doi.org/10.1177/10398562251346619
State	Published - Aug 2025

Bibliographical note

Publisher Copyright:
© The Royal Australian and New Zealand College of Psychiatrists 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Keywords

neurocognition
phenomenology
prodrome
psychosis
schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1177/10398562251346619

Cite this

Barata, V. A., Lavoie, S., Gawęda, Ł., Li, E., Sass, L. A., Koren, D., McGorry, P. D., Jack, B. N., Parnas, J., Polari, A., Allott, K., Hartmann, J. A., Krcmar, M., Rasmussen, A. R., Whitford, T. J., Wannan, C. M. J., & Nelson, B. (2025). The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample. Australasian Psychiatry, 33(4), 736-741. https://doi.org/10.1177/10398562251346619

@article{7135b3ee7de54c78ad7566d8ff55304d,

title = "The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample",

abstract = "Introduction: We previously proposed a neurophenomenological model of schizophrenia, linking basic self-disturbance with neural deficits of source monitoring and aberrant salience. Baseline comparisons in ultra-high risk (UHR) and first-episode psychosis (FEP) samples indicated a relationship between basic self-disturbance and source monitoring deficits, but not aberrant salience. The current paper reports on the 12-month follow-up results in the UHR group (n = 43), focusing on the association between baseline variables and clinical outcomes. Methods: One-way ANOVA compared UHR-remitters (n = 18), UHR-persistent/transitioned to psychosis cases (n = 25) and FEP (n = 38) groups on baseline clinical and neuro-measures. Logistic regression assessed the baseline variables{\textquoteright} predictive power for UHR outcomes. Results: Higher baseline self-disturbance scores (EASE total) were found in the UHR persistence/transition and FEP groups compared to the UHR-remission group, and predicted worse UHR clinical outcomes. Source monitoring deficits were higher in FEP individuals compared to those with UHR persistence/transition. Conclusion: High levels of basic self-disturbance may be a useful predictor marker of poor prognosis in UHR patients.",

keywords = "neurocognition, phenomenology, prodrome, psychosis, schizophrenia",

author = "Barata, \{Vera A.\} and Suzie Lavoie and {\L}ukasz Gaw{\c e}da and Emily Li and Sass, \{Louis A.\} and Danny Koren and McGorry, \{Patrick D.\} and Jack, \{Bradley N.\} and Josef Parnas and Andrea Polari and Kelly Allott and Hartmann, \{Jessica A.\} and Marija Krcmar and Rasmussen, \{Andreas R.\} and Whitford, \{Thomas J.\} and Wannan, \{Cassandra M.J.\} and Barnaby Nelson",

note = "Publisher Copyright: {\textcopyright} The Royal Australian and New Zealand College of Psychiatrists 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).",

year = "2025",

month = aug,

doi = "10.1177/10398562251346619",

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Barata, VA, Lavoie, S, Gawęda, Ł, Li, E, Sass, LA, Koren, D, McGorry, PD, Jack, BN, Parnas, J, Polari, A, Allott, K, Hartmann, JA, Krcmar, M, Rasmussen, AR, Whitford, TJ, Wannan, CMJ & Nelson, B 2025, 'The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample', Australasian Psychiatry, vol. 33, no. 4, pp. 736-741. https://doi.org/10.1177/10398562251346619

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T1 - The neurophenomenology of basic self-disturbance in early psychosis

T2 - Association with clinical outcome in an ultra-high risk sample

AU - Barata, Vera A.

AU - Lavoie, Suzie

AU - Gawęda, Łukasz

AU - Li, Emily

AU - Sass, Louis A.

AU - Koren, Danny

AU - McGorry, Patrick D.

AU - Jack, Bradley N.

AU - Parnas, Josef

AU - Polari, Andrea

AU - Allott, Kelly

AU - Hartmann, Jessica A.

AU - Krcmar, Marija

AU - Rasmussen, Andreas R.

AU - Whitford, Thomas J.

AU - Wannan, Cassandra M.J.

AU - Nelson, Barnaby

N1 - Publisher Copyright: © The Royal Australian and New Zealand College of Psychiatrists 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PY - 2025/8

Y1 - 2025/8

N2 - Introduction: We previously proposed a neurophenomenological model of schizophrenia, linking basic self-disturbance with neural deficits of source monitoring and aberrant salience. Baseline comparisons in ultra-high risk (UHR) and first-episode psychosis (FEP) samples indicated a relationship between basic self-disturbance and source monitoring deficits, but not aberrant salience. The current paper reports on the 12-month follow-up results in the UHR group (n = 43), focusing on the association between baseline variables and clinical outcomes. Methods: One-way ANOVA compared UHR-remitters (n = 18), UHR-persistent/transitioned to psychosis cases (n = 25) and FEP (n = 38) groups on baseline clinical and neuro-measures. Logistic regression assessed the baseline variables’ predictive power for UHR outcomes. Results: Higher baseline self-disturbance scores (EASE total) were found in the UHR persistence/transition and FEP groups compared to the UHR-remission group, and predicted worse UHR clinical outcomes. Source monitoring deficits were higher in FEP individuals compared to those with UHR persistence/transition. Conclusion: High levels of basic self-disturbance may be a useful predictor marker of poor prognosis in UHR patients.

AB - Introduction: We previously proposed a neurophenomenological model of schizophrenia, linking basic self-disturbance with neural deficits of source monitoring and aberrant salience. Baseline comparisons in ultra-high risk (UHR) and first-episode psychosis (FEP) samples indicated a relationship between basic self-disturbance and source monitoring deficits, but not aberrant salience. The current paper reports on the 12-month follow-up results in the UHR group (n = 43), focusing on the association between baseline variables and clinical outcomes. Methods: One-way ANOVA compared UHR-remitters (n = 18), UHR-persistent/transitioned to psychosis cases (n = 25) and FEP (n = 38) groups on baseline clinical and neuro-measures. Logistic regression assessed the baseline variables’ predictive power for UHR outcomes. Results: Higher baseline self-disturbance scores (EASE total) were found in the UHR persistence/transition and FEP groups compared to the UHR-remission group, and predicted worse UHR clinical outcomes. Source monitoring deficits were higher in FEP individuals compared to those with UHR persistence/transition. Conclusion: High levels of basic self-disturbance may be a useful predictor marker of poor prognosis in UHR patients.

KW - neurocognition

KW - phenomenology

KW - prodrome

KW - psychosis

KW - schizophrenia

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DO - 10.1177/10398562251346619

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AN - SCOPUS:105007630947

SN - 1039-8562

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SP - 736

EP - 741

JO - Australasian Psychiatry

JF - Australasian Psychiatry

IS - 4

ER -

The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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