The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress

Research output: Contribution to journalReview articlepeer-review

Abstract

Access of molecular oxygen to the respiratory electron transport chain at the mitochondria costs in the generation of reactive oxygen-derived species (ROS). ROS induces progressive damage to macromolecules in all living cells, hence, rapid defense mechanisms to maintain cellular redox homeostasis are vital. NEDD8/Rub1 is a highly conserved ubiquitin-like modifier that has recently been identified as a key regulator of cellular redox homeostasis. In this review, I will present NEDD8/Rub1, its modification cascade of enzymes, substrates and hydrolases. After introduction, I will show that the NEDD8/Rub1 pathway is linked with mitochondria physiology, namely, oxidative stress. In the rest of the review, I will approach the Ascomycota phylum of the kingdom fungi instrumentally, to present existing links between NEDD8/Rub1 vitality and the aerobic lifestyle of model species belonging to three subphyla: Saccharomycotina (S. cerevisiae and C. albicans), Pezizomycotina (A. nidulans and N. crassa), and Taphrinomycotina (S. pombe).

Original languageEnglish
Article number101765
JournalRedox Biology
Volume37
DOIs
StatePublished - Oct 2020

Bibliographical note

Publisher Copyright:
© 2020

Keywords

  • Ascomycota
  • COP9 signalosome
  • Cullin-RING E3 ligase
  • Mitochondria
  • NEDD8
  • NEDP1
  • Rub1

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Organic Chemistry

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