Abstract
Access of molecular oxygen to the respiratory electron transport chain at the mitochondria costs in the generation of reactive oxygen-derived species (ROS). ROS induces progressive damage to macromolecules in all living cells, hence, rapid defense mechanisms to maintain cellular redox homeostasis are vital. NEDD8/Rub1 is a highly conserved ubiquitin-like modifier that has recently been identified as a key regulator of cellular redox homeostasis. In this review, I will present NEDD8/Rub1, its modification cascade of enzymes, substrates and hydrolases. After introduction, I will show that the NEDD8/Rub1 pathway is linked with mitochondria physiology, namely, oxidative stress. In the rest of the review, I will approach the Ascomycota phylum of the kingdom fungi instrumentally, to present existing links between NEDD8/Rub1 vitality and the aerobic lifestyle of model species belonging to three subphyla: Saccharomycotina (S. cerevisiae and C. albicans), Pezizomycotina (A. nidulans and N. crassa), and Taphrinomycotina (S. pombe).
| Original language | English |
|---|---|
| Article number | 101765 |
| Journal | Redox Biology |
| Volume | 37 |
| DOIs | |
| State | Published - Oct 2020 |
Bibliographical note
Funding Information:I would like to thank the ISF grant number 162/2017 for funding the studies in my lab.
Publisher Copyright:
© 2020
Keywords
- Ascomycota
- COP9 signalosome
- Cullin-RING E3 ligase
- Mitochondria
- NEDD8
- NEDP1
- Rub1
ASJC Scopus subject areas
- Organic Chemistry
- Clinical Biochemistry