The Multipartite Mitochondrial Genome of Enteromyxum leei (Myxozoa): Eight Fast-Evolving Megacircles

Dayana Yahalomi; Michal Haddas-Sasson; Nimrod D. Rubinstein; Tamar Feldstein; Arik Diamant; Dorothée Huchon

doi:10.1093/MOLBEV/MSX072

The Multipartite Mitochondrial Genome of Enteromyxum leei (Myxozoa): Eight Fast-Evolving Megacircles

Dayana Yahalomi, Michal Haddas-Sasson, Nimrod D. Rubinstein, Tamar Feldstein, Arik Diamant, Dorothée Huchon

Research output: Contribution to journal › Article › peer-review

Abstract

Myxozoans are a large group of poorly characterized cnidarian parasites. To gain further insight into their evolution, we sequenced the mitochondrial (mt) genome of Enteromyxum leei and reevaluate the mt genome structure of Kudoa iwatai. Although the typical animal mt genome is a compact, 13–25 kb, circular chromosome, the mt genome of E. leei was found to be fragmented into eight circular chromosomes of ~23 kb, making it the largest described animal mt genome. Each chromosome was found to harbor a large noncoding region (~15 kb), nearly identical between chromosomes. The protein coding genes show an unusually high rate of sequence evolution and possess little similarity to their cnidarian homologs. Only five protein coding genes could be identified and no tRNA genes. Surprisingly, the mt genome of K. iwatai was also found to be composed of two chromosomes. These observations confirm the remarkable plasticity of myxozoan mt genomes.

Original language	English
Pages (from-to)	1551-1556
Number of pages	6
Journal	Molecular Biology and Evolution
Volume	34
Issue number	7
DOIs	https://doi.org/10.1093/MOLBEV/MSX072
State	Published - 1 Jul 2017
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Naomi Paz for editing the text, Dennis Lavrov for suggesting to search for the MRPP3 gene, the associate editor and four anonymous reviewers for their helpful comments and suggestions. This work was supported by the Israel Science Foundation 663/10 to D.H.

Publisher Copyright:
© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.

Keywords

Cnidaria
gene conversion
mtDNA
Myxosporea
tRNA loss

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

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10.1093/MOLBEV/MSX072

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title = "The Multipartite Mitochondrial Genome of Enteromyxum leei (Myxozoa): Eight Fast-Evolving Megacircles",

abstract = "Myxozoans are a large group of poorly characterized cnidarian parasites. To gain further insight into their evolution, we sequenced the mitochondrial (mt) genome of Enteromyxum leei and reevaluate the mt genome structure of Kudoa iwatai. Although the typical animal mt genome is a compact, 13–25 kb, circular chromosome, the mt genome of E. leei was found to be fragmented into eight circular chromosomes of ~23 kb, making it the largest described animal mt genome. Each chromosome was found to harbor a large noncoding region (~15 kb), nearly identical between chromosomes. The protein coding genes show an unusually high rate of sequence evolution and possess little similarity to their cnidarian homologs. Only five protein coding genes could be identified and no tRNA genes. Surprisingly, the mt genome of K. iwatai was also found to be composed of two chromosomes. These observations confirm the remarkable plasticity of myxozoan mt genomes.",

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N1 - Funding Information: We would like to thank Naomi Paz for editing the text, Dennis Lavrov for suggesting to search for the MRPP3 gene, the associate editor and four anonymous reviewers for their helpful comments and suggestions. This work was supported by the Israel Science Foundation 663/10 to D.H. Publisher Copyright: © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.

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N2 - Myxozoans are a large group of poorly characterized cnidarian parasites. To gain further insight into their evolution, we sequenced the mitochondrial (mt) genome of Enteromyxum leei and reevaluate the mt genome structure of Kudoa iwatai. Although the typical animal mt genome is a compact, 13–25 kb, circular chromosome, the mt genome of E. leei was found to be fragmented into eight circular chromosomes of ~23 kb, making it the largest described animal mt genome. Each chromosome was found to harbor a large noncoding region (~15 kb), nearly identical between chromosomes. The protein coding genes show an unusually high rate of sequence evolution and possess little similarity to their cnidarian homologs. Only five protein coding genes could be identified and no tRNA genes. Surprisingly, the mt genome of K. iwatai was also found to be composed of two chromosomes. These observations confirm the remarkable plasticity of myxozoan mt genomes.

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The Multipartite Mitochondrial Genome of Enteromyxum leei (Myxozoa): Eight Fast-Evolving Megacircles

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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