The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development

Yonatan Feuermann; Gertraud W. Robinson; Bing Mei Zhu; Keunsoo Kang; Noa Raviv; Daisuke Yamaji; Lothar Hennighausen

doi:10.1002/dvg.22023

The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development

Yonatan Feuermann
, Gertraud W. Robinson
, Bing Mei Zhu
, Keunsoo Kang
, Noa Raviv
, Daisuke Yamaji
, Lothar Hennighausen

Research output: Contribution to journal › Article › peer-review

Abstract

Genome wide analysis revealed the miR-17/92 cluster as a STAT5 target. This cluster encodes six microRNAs, which predictably target genes that play a role in mammary gland development. In this study, we have deleted the miR-17/92 cluster in mammary stem cells and evaluated in the mouse its function during mammary gland development. Loss of the miR-17/92 cluster did not affect mammary development from prepuberty to lactation. Our studies demonstrated that, while expression of the miR-17/92 cluster is under control of the key mammary transcription factor STAT5, its presence is not required for normal mammary development or lactation.

Original language	English
Pages (from-to)	665-671
Number of pages	7
Journal	Genesis (United States)
Volume	50
Issue number	9
DOIs	https://doi.org/10.1002/dvg.22023
State	Published - Sep 2012
Externally published	Yes

Keywords

Mammary gland
MiR-17/92 cluster
STAT5

ASJC Scopus subject areas

Genetics
Endocrinology
Cell Biology

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10.1002/dvg.22023

Cite this

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title = "The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development",

abstract = "Genome wide analysis revealed the miR-17/92 cluster as a STAT5 target. This cluster encodes six microRNAs, which predictably target genes that play a role in mammary gland development. In this study, we have deleted the miR-17/92 cluster in mammary stem cells and evaluated in the mouse its function during mammary gland development. Loss of the miR-17/92 cluster did not affect mammary development from prepuberty to lactation. Our studies demonstrated that, while expression of the miR-17/92 cluster is under control of the key mammary transcription factor STAT5, its presence is not required for normal mammary development or lactation.",

keywords = "Mammary gland, MiR-17/92 cluster, STAT5",

author = "Yonatan Feuermann and Robinson, \{Gertraud W.\} and Zhu, \{Bing Mei\} and Keunsoo Kang and Noa Raviv and Daisuke Yamaji and Lothar Hennighausen",

year = "2012",

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AU - Feuermann, Yonatan

AU - Robinson, Gertraud W.

AU - Zhu, Bing Mei

AU - Kang, Keunsoo

AU - Raviv, Noa

AU - Yamaji, Daisuke

AU - Hennighausen, Lothar

PY - 2012/9

Y1 - 2012/9

N2 - Genome wide analysis revealed the miR-17/92 cluster as a STAT5 target. This cluster encodes six microRNAs, which predictably target genes that play a role in mammary gland development. In this study, we have deleted the miR-17/92 cluster in mammary stem cells and evaluated in the mouse its function during mammary gland development. Loss of the miR-17/92 cluster did not affect mammary development from prepuberty to lactation. Our studies demonstrated that, while expression of the miR-17/92 cluster is under control of the key mammary transcription factor STAT5, its presence is not required for normal mammary development or lactation.

AB - Genome wide analysis revealed the miR-17/92 cluster as a STAT5 target. This cluster encodes six microRNAs, which predictably target genes that play a role in mammary gland development. In this study, we have deleted the miR-17/92 cluster in mammary stem cells and evaluated in the mouse its function during mammary gland development. Loss of the miR-17/92 cluster did not affect mammary development from prepuberty to lactation. Our studies demonstrated that, while expression of the miR-17/92 cluster is under control of the key mammary transcription factor STAT5, its presence is not required for normal mammary development or lactation.

KW - Mammary gland

KW - MiR-17/92 cluster

KW - STAT5

UR - https://www.scopus.com/pages/publications/84866628441

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DO - 10.1002/dvg.22023

M3 - Article

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AN - SCOPUS:84866628441

SN - 1526-954X

VL - 50

SP - 665

EP - 671

JO - Genesis (United States)

JF - Genesis (United States)

IS - 9

ER -

The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development

Abstract

Keywords

ASJC Scopus subject areas

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