The interhemispheric CA1 circuit governs rapid generalisation but not fear memory

Heng Zhou, Gui Jing Xiong, Liang Jing, Ning Ning Song, De Lin Pu, Xun Tang, Xiao Bing He, Fu Qiang Xu, Jing Fei Huang, Ling Jiang Li, Gal Richter-Levin, Rong Rong Mao, Qi Xin Zhou, Yu Qiang Ding, Lin Xu

Research output: Contribution to journalArticlepeer-review


Encoding specificity theory predicts most effective recall by the original conditions at encoding, while generalization endows recall flexibly under circumstances which deviate from the originals. The CA1 regions have been implicated in memory and generalization but whether and which locally separated mechanisms are involved is not clear. We report here that fear memory is quickly formed, but generalization develops gradually over 24 h. Generalization but not fear memory is impaired by inhibiting ipsilateral (ips) or contralateral (con) CA1, and by optogenetic silencing of the ipsCA1 projections onto conCA1. By contrast, in vivo fEPSP recordings reveal that ipsCA1-conCA1 synaptic efficacy is increased with delay over 24 h when generalization is formed but it is unchanged if generalization is disrupted. Direct excitation of ipsCA1-conCA1 synapses using chemogenetic hM3Dq facilitates generalization formation. Thus, rapid generalization is an active process dependent on bilateral CA1 regions, and encoded by gradual synaptic learning in ipsCA1-conCA1 circuit.

Original languageEnglish
Article number2190
JournalNature Communications
Issue number1
StatePublished - 1 Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy


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