The influence of the recombinant human heat shock protein hsp70 on the biochemical properties of blood during endotoxic shock simulation in rats

V. F. Ostrov; G. A. Slashcheva; T. Yu Zharmukhamedova; D. G. Garbuz; M. B. Evgen'ev; A. N. Murashev

doi:10.1134/S1068162010030052

The influence of the recombinant human heat shock protein hsp70 on the biochemical properties of blood during endotoxic shock simulation in rats

V. F. Ostrov, G. A. Slashcheva, T. Yu Zharmukhamedova, D. G. Garbuz, M. B. Evgen'ev, A. N. Murashev

Research output: Contribution to journal › Article › peer-review

Abstract

The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous injection in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coli endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

Original language	English
Pages (from-to)	310-314
Number of pages	5
Journal	Russian Journal of Bioorganic Chemistry
Volume	36
Issue number	3
DOIs	https://doi.org/10.1134/S1068162010030052
State	Published - May 2010
Externally published	Yes

Keywords

Blood biochemical parameters
Endotoxic shock
Heat shock proteins
Lipopolysaccharides

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1134/S1068162010030052

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title = "The influence of the recombinant human heat shock protein hsp70 on the biochemical properties of blood during endotoxic shock simulation in rats",

abstract = "The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous injection in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coli endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.",

keywords = "Blood biochemical parameters, Endotoxic shock, Heat shock proteins, Lipopolysaccharides",

author = "Ostrov, {V. F.} and Slashcheva, {G. A.} and Zharmukhamedova, {T. Yu} and Garbuz, {D. G.} and Evgen'ev, {M. B.} and Murashev, {A. N.}",

year = "2010",

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doi = "10.1134/S1068162010030052",

language = "English",

volume = "36",

pages = "310--314",

journal = "Russian Journal of Bioorganic Chemistry",

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AU - Ostrov, V. F.

AU - Slashcheva, G. A.

AU - Zharmukhamedova, T. Yu

AU - Garbuz, D. G.

AU - Evgen'ev, M. B.

AU - Murashev, A. N.

PY - 2010/5

Y1 - 2010/5

N2 - The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous injection in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coli endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

AB - The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous injection in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coli endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

KW - Blood biochemical parameters

KW - Endotoxic shock

KW - Heat shock proteins

KW - Lipopolysaccharides

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U2 - 10.1134/S1068162010030052

DO - 10.1134/S1068162010030052

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SP - 310

EP - 314

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

IS - 3

ER -

The influence of the recombinant human heat shock protein hsp70 on the biochemical properties of blood during endotoxic shock simulation in rats

Abstract

Keywords

ASJC Scopus subject areas

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