The impact of skin care products on skin chemistry and microbiome dynamics

Amina Bouslimani; Ricardo Da Silva; Tomasz Kosciolek; Stefan Janssen; Chris Callewaert; Amnon Amir; Kathleen Dorrestein; Alexey V. Melnik; Livia S. Zaramela; Ji Nu Kim; Gregory Humphrey; Tara Schwartz; Karenina Sanders; Caitriona Brennan; Tal Luzzatto-Knaan; Gail Ackermann; Daniel McDonald; Karsten Zengler; Rob Knight; Pieter C. Dorrestein

doi:10.1186/s12915-019-0660-6

The impact of skin care products on skin chemistry and microbiome dynamics

Amina Bouslimani, Ricardo Da Silva, Tomasz Kosciolek, Stefan Janssen, Chris Callewaert, Amnon Amir, Kathleen Dorrestein, Alexey V. Melnik, Livia S. Zaramela, Ji Nu Kim, Gregory Humphrey, Tara Schwartz, Karenina Sanders, Caitriona Brennan, Tal Luzzatto-Knaan, Gail Ackermann, Daniel McDonald, Karsten Zengler, Rob Knight, Pieter C. Dorrestein

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks. Results: Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics. Conclusions: These findings may lead to next-generation precision beauty products and therapies for skin disorders.

Original language	English
Article number	47
Journal	BMC Biology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12915-019-0660-6
State	Published - 12 Jun 2019
Externally published	Yes

Bibliographical note

Funding Information:
This work was partially supported by US National Institutes of Health (NIH) Grant. P.C.D. acknowledges funding from the European Union’s Horizon 2020 Programme (Grant 634402). A.B was supported by the National Institute of Justice Award 2015-DN-BX-K047. C.C. was supported by a fellowship of the Belgian American Educational Foundation and the Research Foundation Flanders. L.Z., J.K, and K.Z. acknowledge funding from the US National Institutes of Health under Grant No. AR071731. TLK was supported by Vaadia-BARD Postdoctoral Fellowship Award No. FI-494-13.

Publisher Copyright:
© 2019 The Author(s).

Keywords

16S rRNA sequencing
Bacteria
Mass spectrometry
Metabolomics
Skin
Skin care products

ASJC Scopus subject areas

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
Biochemistry, Genetics and Molecular Biology (all)
Agricultural and Biological Sciences (all)
Plant Science
Developmental Biology
Cell Biology

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10.1186/s12915-019-0660-6

Cite this

Bouslimani, A., Da Silva, R., Kosciolek, T., Janssen, S., Callewaert, C., Amir, A., Dorrestein, K., Melnik, A. V., Zaramela, L. S., Kim, J. N., Humphrey, G., Schwartz, T., Sanders, K., Brennan, C., Luzzatto-Knaan, T., Ackermann, G., McDonald, D., Zengler, K., Knight, R., & Dorrestein, P. C. (2019). The impact of skin care products on skin chemistry and microbiome dynamics. BMC Biology, 17(1), [47]. https://doi.org/10.1186/s12915-019-0660-6

@article{48a7a30d0bd14533b18783d232b593c6,

title = "The impact of skin care products on skin chemistry and microbiome dynamics",

abstract = "Background: Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks. Results: Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics. Conclusions: These findings may lead to next-generation precision beauty products and therapies for skin disorders.",

keywords = "16S rRNA sequencing, Bacteria, Mass spectrometry, Metabolomics, Skin, Skin care products",

author = "Amina Bouslimani and {Da Silva}, Ricardo and Tomasz Kosciolek and Stefan Janssen and Chris Callewaert and Amnon Amir and Kathleen Dorrestein and Melnik, {Alexey V.} and Zaramela, {Livia S.} and Kim, {Ji Nu} and Gregory Humphrey and Tara Schwartz and Karenina Sanders and Caitriona Brennan and Tal Luzzatto-Knaan and Gail Ackermann and Daniel McDonald and Karsten Zengler and Rob Knight and Dorrestein, {Pieter C.}",

note = "Funding Information: This work was partially supported by US National Institutes of Health (NIH) Grant. P.C.D. acknowledges funding from the European Union{\textquoteright}s Horizon 2020 Programme (Grant 634402). A.B was supported by the National Institute of Justice Award 2015-DN-BX-K047. C.C. was supported by a fellowship of the Belgian American Educational Foundation and the Research Foundation Flanders. L.Z., J.K, and K.Z. acknowledge funding from the US National Institutes of Health under Grant No. AR071731. TLK was supported by Vaadia-BARD Postdoctoral Fellowship Award No. FI-494-13. Publisher Copyright: {\textcopyright} 2019 The Author(s).",

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Bouslimani, A, Da Silva, R, Kosciolek, T, Janssen, S, Callewaert, C, Amir, A, Dorrestein, K, Melnik, AV, Zaramela, LS, Kim, JN, Humphrey, G, Schwartz, T, Sanders, K, Brennan, C, Luzzatto-Knaan, T, Ackermann, G, McDonald, D, Zengler, K, Knight, R & Dorrestein, PC 2019, 'The impact of skin care products on skin chemistry and microbiome dynamics', BMC Biology, vol. 17, no. 1, 47. https://doi.org/10.1186/s12915-019-0660-6

TY - JOUR

T1 - The impact of skin care products on skin chemistry and microbiome dynamics

AU - Bouslimani, Amina

AU - Da Silva, Ricardo

AU - Kosciolek, Tomasz

AU - Janssen, Stefan

AU - Callewaert, Chris

AU - Amir, Amnon

AU - Dorrestein, Kathleen

AU - Melnik, Alexey V.

AU - Zaramela, Livia S.

AU - Kim, Ji Nu

AU - Humphrey, Gregory

AU - Schwartz, Tara

AU - Sanders, Karenina

AU - Brennan, Caitriona

AU - Luzzatto-Knaan, Tal

AU - Ackermann, Gail

AU - McDonald, Daniel

AU - Zengler, Karsten

AU - Knight, Rob

AU - Dorrestein, Pieter C.

N1 - Funding Information: This work was partially supported by US National Institutes of Health (NIH) Grant. P.C.D. acknowledges funding from the European Union’s Horizon 2020 Programme (Grant 634402). A.B was supported by the National Institute of Justice Award 2015-DN-BX-K047. C.C. was supported by a fellowship of the Belgian American Educational Foundation and the Research Foundation Flanders. L.Z., J.K, and K.Z. acknowledge funding from the US National Institutes of Health under Grant No. AR071731. TLK was supported by Vaadia-BARD Postdoctoral Fellowship Award No. FI-494-13. Publisher Copyright: © 2019 The Author(s).

PY - 2019/6/12

Y1 - 2019/6/12

N2 - Background: Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks. Results: Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics. Conclusions: These findings may lead to next-generation precision beauty products and therapies for skin disorders.

AB - Background: Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks. Results: Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics. Conclusions: These findings may lead to next-generation precision beauty products and therapies for skin disorders.

KW - 16S rRNA sequencing

KW - Bacteria

KW - Mass spectrometry

KW - Metabolomics

KW - Skin

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JO - BMC Biology

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SN - 1741-7007

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ER -

The impact of skin care products on skin chemistry and microbiome dynamics

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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