The hijacking of a receptor kinase-driven pathway by a wheat fungal pathogen leads to disease

Gongjun Shi, Zengcui Zhang, Timothy L. Friesen, Dina Raats, Tzion Fahima, Robert S. Brueggeman, Shunwen Lu, Harold N. Trick, Zhaohui Liu, Wun Chao, Zeev Frenkel, Steven S. Xu, Jack B. Rasmussen, Justin D. Faris

Research output: Contribution to journalArticlepeer-review


Necrotrophic pathogens live and feed on dying tissue, but their interactions with plants are not well understood compared to biotrophic pathogens. The wheat Snn1 gene confers susceptibility to strains of the necrotrophic pathogen Parastagonospora nodorum that produce the SnTox1 protein. We report the positional cloning of Snn1, a member of the wall-associated kinase class of receptors, which are known to drive pathways for biotrophic pathogen resistance. Recognition of SnTox1 by Snn1 activates programmed cell death, which allows this necrotroph to gain nutrients and sporulate. These results demonstrate that necrotrophic pathogens such as P. nodorum hijack host molecular pathways that are typically involved in resistance to biotrophic pathogens, revealing the complex nature of susceptibility and resistance in necrotrophic and biotrophic pathogen interactions with plants.

Original languageEnglish
Article number1600822
JournalScience advances
Issue number10
StatePublished - Oct 2016

Bibliographical note

Publisher Copyright:
© 2016 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

ASJC Scopus subject areas

  • General


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