The evidence for a microRNA product of human DROSHA gene

Peter Mechtler, Sydney Johnson, Hannah Slabodkin, Amir B. Cohanim, Leonid Brodsky, Eugene S. Kandel

Research output: Contribution to journalArticlepeer-review


MicroRNAs are short RNA molecules that regulate function and stability of a large subset of eukaryotic mRNAs. In the main pathway of microRNA biogenesis, a short “hairpin” is excised from a primary transcript by ribonuclease DROSHA, followed by additional nucleolytic processing by DICER and inclusion of the mature microRNA into the RNA-induced silencing complex. We report that a microRNA-like molecule is encoded by human DROSHA gene within a predicted stem-loop element of the respective transcript. This putative mature microRNA is complementary to DROSHA transcript variant 1 and can attenuate expression of the corresponding protein. The findings suggest a possibility for a negative feedback loop, wherein DROSHA processes its own transcript and produces an inhibitor of its own biosynthesis.

Original languageEnglish
Pages (from-to)1508-1513
Number of pages6
JournalRNA Biology
Issue number11
StatePublished - 2 Nov 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis Group, LLC.


  • RNA interference
  • microRNA biogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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