The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

M. A. Aleksandrova; G. V. Pavlova; A. V. Revishchin; V. N. Bashkirov; E. A. Modestova; M. B. Evgen'ev; I. N. Saburina; I. B. Mertsalov; S. P. Vengrova; L. I. Korochkin

The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

M. A. Aleksandrova, G. V. Pavlova, A. V. Revishchin, V. N. Bashkirov, E. A. Modestova, M. B. Evgen'ev, I. N. Saburina, I. B. Mertsalov, S. P. Vengrova, L. I. Korochkin

Research output: Contribution to journal › Article › peer-review

Abstract

A transgenic line of Drosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.

Original language	English
Pages (from-to)	1308-1314
Number of pages	7
Journal	Russian Journal of Genetics
Volume	36
Issue number	11
State	Published - Nov 2000
Externally published	Yes

ASJC Scopus subject areas

Genetics

Cite this

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title = "The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain",

abstract = "A transgenic line of Drosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.",

author = "Aleksandrova, {M. A.} and Pavlova, {G. V.} and Revishchin, {A. V.} and Bashkirov, {V. N.} and Modestova, {E. A.} and Evgen'ev, {M. B.} and Saburina, {I. N.} and Mertsalov, {I. B.} and Vengrova, {S. P.} and Korochkin, {L. I.}",

year = "2000",

month = nov,

language = "English",

volume = "36",

pages = "1308--1314",

journal = "Russian Journal of Genetics",

issn = "1022-7954",

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TY - JOUR

T1 - The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

AU - Aleksandrova, M. A.

AU - Pavlova, G. V.

AU - Revishchin, A. V.

AU - Bashkirov, V. N.

AU - Modestova, E. A.

AU - Evgen'ev, M. B.

AU - Saburina, I. N.

AU - Mertsalov, I. B.

AU - Vengrova, S. P.

AU - Korochkin, L. I.

PY - 2000/11

Y1 - 2000/11

N2 - A transgenic line of Drosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.

AB - A transgenic line of Drosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.

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M3 - Article

AN - SCOPUS:0041963028

SN - 1022-7954

VL - 36

SP - 1308

EP - 1314

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

IS - 11

ER -

The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

Abstract

ASJC Scopus subject areas

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