The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

M. A. Aleksandrova; G. V. Pavlova; A. V. Revishchin; V. N. Bashkirov; E. A. Modestova; M. B. Evgen'Ev; I. N. Saburina; I. B. Mertsalov; S. P. Vengrova; L. I. Korochkin

The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

M. A. Aleksandrova, G. V. Pavlova, A. V. Revishchin, V. N. Bashkirov, E. A. Modestova, M. B. Evgen'Ev, I. N. Saburina, I. B. Mertsalov, S. P. Vengrova, L. I. Korochkin

Research output: Contribution to journal › Article › peer-review

Abstract

A transgenic line ofDrosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.

Original language	English
Pages (from-to)	1553-1560
Number of pages	8
Journal	Genetika
Volume	36
Issue number	11
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain",

abstract = "A transgenic line ofDrosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.",

author = "Aleksandrova, {M. A.} and Pavlova, {G. V.} and Revishchin, {A. V.} and Bashkirov, {V. N.} and Modestova, {E. A.} and Evgen'Ev, {M. B.} and Saburina, {I. N.} and Mertsalov, {I. B.} and Vengrova, {S. P.} and Korochkin, {L. I.}",

year = "2000",

language = "English",

volume = "36",

pages = "1553--1560",

journal = "Genetika",

issn = "0016-6758",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "11",

}

TY - JOUR

T1 - The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

AU - Aleksandrova, M. A.

AU - Pavlova, G. V.

AU - Revishchin, A. V.

AU - Bashkirov, V. N.

AU - Modestova, E. A.

AU - Evgen'Ev, M. B.

AU - Saburina, I. N.

AU - Mertsalov, I. B.

AU - Vengrova, S. P.

AU - Korochkin, L. I.

PY - 2000

Y1 - 2000

N2 - A transgenic line ofDrosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.

AB - A transgenic line ofDrosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.

UR - http://www.scopus.com/inward/record.url?scp=0034320324&partnerID=8YFLogxK

M3 - Article

C2 - 11094774

AN - SCOPUS:0034320324

SN - 0016-6758

VL - 36

SP - 1553

EP - 1560

JO - Genetika

JF - Genetika

IS - 11

ER -

The effect of the alien gene GDNF on the development of homo- and xenografts in the rat brain

Abstract

ASJC Scopus subject areas

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