The Effect of Mood on Sleep Onset Latency and REM Sleep in Interepisode Bipolar Disorder

Lisa S. Talbot, Ilana S. Hairston, Polina Eidelman, June Gruber, Allison G. Harvey

Research output: Contribution to journalArticlepeer-review


The present study investigates whether interepisode mood regulation impairment contributes to disturbances in sleep onset latency (SOL) and rapid eye movement (REM) sleep. Individuals with interepisode bipolar disorder (n = 28) and healthy controls (n = 28) slept in the laboratory for 2 baseline nights, a happy mood induction night, and a sad mood induction night. There was a significant interaction whereby on the happy mood induction night the bipolar group exhibited significantly longer SOL than did the control group, while there was no difference on the baseline nights. In addition, control participants exhibited shorter SOL on the happy mood induction night compared to the baseline nights, a finding that was not observed in the bipolar group. On the sad mood induction night, participants in both groups had shorter SOL and increased REM density when compared to the baseline nights. Bipolar participants exhibited heightened REM density compared to control participants on both nights. These results raise the possibility that regulation of positive stimuli may be a contributor to difficulties with SOL, while hyperactivity may be characteristic of REM sleep.

Original languageEnglish
Pages (from-to)448-458
Number of pages11
JournalJournal of Abnormal Psychology
Issue number3
StatePublished - Aug 2009
Externally publishedYes


  • REM sleep
  • bipolar disorder
  • interepisode
  • mood induction
  • sleep onset latency

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'The Effect of Mood on Sleep Onset Latency and REM Sleep in Interepisode Bipolar Disorder'. Together they form a unique fingerprint.

Cite this