The effect of 5‐hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine

J. E. BLUNDELL; M. B. LESHEM

doi:10.1111/j.2042-7158.1975.tb09374.x

The effect of 5‐hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine

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Abstract

5‐Hydroxytryptophan (5‐HTP), amphetamine and fenfluramine suppressed food intake in normal rats and in animals with lesions of the lateral hypothalamus. The anorexic effect of amphetamine was reduced in lesioned animals compared with controls while the effect of 5‐HTP like that of fenfluramine was increased. When administered in conjunction with the anorexic drugs, 5‐HTP markedly potentiated the anorexic effect of amphetamine in both control and lesioned animals. However, 5‐HTP potentiated fenfluramine anorexia only in lesioned rats. These findings provide further evidence for the role of 5‐hydroxytryptamine (5‐HT), in the anorexic effect of fenfluramine, and suggest that a 5‐HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions. 1975 Royal Pharmaceutical Society of Great Britain

Original language	English
Pages (from-to)	31-37
Number of pages	7
Journal	Journal of Pharmacy and Pharmacology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1111/j.2042-7158.1975.tb09374.x
State	Published - Jan 1975
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1111/j.2042-7158.1975.tb09374.x

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title = "The effect of 5‐hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine",

abstract = "5‐Hydroxytryptophan (5‐HTP), amphetamine and fenfluramine suppressed food intake in normal rats and in animals with lesions of the lateral hypothalamus. The anorexic effect of amphetamine was reduced in lesioned animals compared with controls while the effect of 5‐HTP like that of fenfluramine was increased. When administered in conjunction with the anorexic drugs, 5‐HTP markedly potentiated the anorexic effect of amphetamine in both control and lesioned animals. However, 5‐HTP potentiated fenfluramine anorexia only in lesioned rats. These findings provide further evidence for the role of 5‐hydroxytryptamine (5‐HT), in the anorexic effect of fenfluramine, and suggest that a 5‐HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions. 1975 Royal Pharmaceutical Society of Great Britain",

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N2 - 5‐Hydroxytryptophan (5‐HTP), amphetamine and fenfluramine suppressed food intake in normal rats and in animals with lesions of the lateral hypothalamus. The anorexic effect of amphetamine was reduced in lesioned animals compared with controls while the effect of 5‐HTP like that of fenfluramine was increased. When administered in conjunction with the anorexic drugs, 5‐HTP markedly potentiated the anorexic effect of amphetamine in both control and lesioned animals. However, 5‐HTP potentiated fenfluramine anorexia only in lesioned rats. These findings provide further evidence for the role of 5‐hydroxytryptamine (5‐HT), in the anorexic effect of fenfluramine, and suggest that a 5‐HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions. 1975 Royal Pharmaceutical Society of Great Britain

AB - 5‐Hydroxytryptophan (5‐HTP), amphetamine and fenfluramine suppressed food intake in normal rats and in animals with lesions of the lateral hypothalamus. The anorexic effect of amphetamine was reduced in lesioned animals compared with controls while the effect of 5‐HTP like that of fenfluramine was increased. When administered in conjunction with the anorexic drugs, 5‐HTP markedly potentiated the anorexic effect of amphetamine in both control and lesioned animals. However, 5‐HTP potentiated fenfluramine anorexia only in lesioned rats. These findings provide further evidence for the role of 5‐hydroxytryptamine (5‐HT), in the anorexic effect of fenfluramine, and suggest that a 5‐HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions. 1975 Royal Pharmaceutical Society of Great Britain

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The effect of 5‐hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine

Abstract

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