Abstract
The Anterior Burster (AB) neuron of the lobster stomatogastric ganglion displays varied behavior when subjected to application of neu- romodulators and toxins. We introduce a new, channel based model for this neuron and investigate the response of this model to changes of its parameters. An efficient computational environment aids in the determination of the bifurcations in the model, separating regions of the parameter space with different types of behavior. The model pre- dictions compare well with a limited set of experimental data.
Different two dimensional slices of the parameter space are mapped. They correspond to the application of specific-channel blockers to an experimental preparation. These mapped regions are used to predict the effects of Dopamine on the AB cell ion channels, and to suggest some experiments to support these conjectures.
Different two dimensional slices of the parameter space are mapped. They correspond to the application of specific-channel blockers to an experimental preparation. These mapped regions are used to predict the effects of Dopamine on the AB cell ion channels, and to suggest some experiments to support these conjectures.
Original language | English |
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Pages (from-to) | A98 |
Number of pages | 1 |
Journal | Biophysical Journal |
Volume | 64 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1993 |
Externally published | Yes |