The core transcriptome of mammalian placentas and the divergence of expression with placental shape

Don L. Armstrong, Michael R. McGowen, Amy Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage-Rumbaugh, Eviatar Nevo, Chong J. Kim, Günter P. Wagner, Roberto Romero, Derek E. Wildman

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction The placenta is arguably the most anatomically variable organ in mammals even though its primary function is conserved. Method Using RNA-Seq, we measured the expression profiles of 55 term placentas of 14 species of mammals representing all major eutherian superordinal clades and marsupials, and compared the evolution of expression across clades. Results We identified a set of 115 core genes which is expressed (FPKM ≥10) in all eutherian placentas, including genes with immune-modulating properties (ANXA2, ANXA1, S100A11, S100A10, and LGALS1), cell-cell interactions (LAMC1, LUM, and LGALS1), invasion (GRB2 and RALB) and syncytialization (ANXA5 and ANXA1). We also identified multiple pre-eclampsia associated genes which are differentially expressed in Homo sapiens when compared to the other 13 species. Multiple genes are significantly associated with placenta morphology, including EREG and WNT5A which are both associated with placental shape. Discussion 115 genes are important for the core functions of the placenta in all eutherian species analyzed. The molecular functions and pathways enriched in the core placenta align with the evolutionarily conserved functionality of the placenta.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalPlacenta
Volume57
DOIs
StatePublished - Sep 2017

Bibliographical note

Funding Information:
Partial support for this research came from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (N01-HD-3342), the National Science Foundation (BCS-0827546 and BCS-0751508), the Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Federal funds from NICHD/NIH/DHHS under Contract No.HHSN275201300006C, and a seed grant from the Institute for Genomic Biology at the University of Illinois, Urbana-Champaign.

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • Evolution
  • Gene expression
  • Mammal
  • Placenta
  • RNA-Seq

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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