Abstract
Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from a specific ratio of two free polyunsaturated fatty acids - linoleic acid and α-linolenic acid - the eye blinking rate following administration of Ro4-1284 is reduced to saline and no drug control levels. These results suggest a favorable prospect for essential fatty acids in general, and SR-3 in particular, to provide an improved therapeutic option for the clinical management of benign essential blepharospasm. Copyright (C) 2000 S. Karger AG, Basel.
| Original language | English |
|---|---|
| Pages (from-to) | 154-157 |
| Number of pages | 4 |
| Journal | Neuropsychobiology |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
Keywords
- Blepharospasm
- Dopamine deficiency
- Fatty acids
- Linoleic acid
- α-linolenic acid
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Psychiatry and Mental health
- Biological Psychiatry