The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015

Ravit Bassal, Tamy Shohat, Tal Levin, Rakefet Pando, Eilat Shinar, Doron Amichay, Mira Barak, Anat Ben-Dor, Adina Bar-Haim, Ella Mendelson, Dani Cohen, Lital Keinan-Boker, Victoria Indenbaum

Research output: Contribution to journalArticlepeer-review

Abstract

Mumps and rubella are vaccine-preventable viral diseases through the measles-mumps-rubella-varicella (MMRV) vaccine, administered at 12 months and again at 6 years. We assessed the sero-prevalence of mumps and rubella, identified factors associated with sero-negativity, and eval-uated concordance between mumps and rubella sero-positivity. A national cross-sectional sero-sur-vey was conducted on samples collected in 2015 by the Israel National Sera Bank. Samples were tested for mumps and rubella IgG antibodies using an enzyme-linked immunosorbent assay. Of 3131 samples tested for mumps IgG, 84.8% (95%CI: 83.5–86.0%) were sero-positive. Sero-negativity for mumps was significantly associated with age (high odds ratios observed in infants younger than 4 years and 20–29 years old subjects). Of 3169 samples tested for rubella IgG antibodies, 95.2% (95%CI: 94.4–95.9%) were sero-positive. Rubella sero-negativity was significantly associated with age (high odds ratios observed in children younger than 4 years old and adults older than 30 years), males, Jews, and others. Concordant sero-positivity for both mumps and rubella viruses was observed in 83.9% of the tested samples. The Israeli population was sufficiently protected against rubella but not against mumps. Since both components are administered in the MMRV vaccine sim-ultaneously, the mumps component has a lower uptake than rubella and quicker waning.

Original languageEnglish
Article number996
JournalVaccines
Volume10
Issue number7
DOIs
StatePublished - Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • mumps
  • rubella
  • sero-prevalence
  • vaccine
  • virus

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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