The Burden of Coronavirus Disease 2019 and Its Complications in Patients With Atopic Dermatitis - A Nested Case-Control Study

Khalaf Kridin, Yochai Schonmann, Dana Tzur Bitan, Giovanni Damiani, Orly Weinstein, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review


Background The burden of coronavirus disease 2019 (COVID-19) among patients with atopic dermatitis (AD) is poorly understood. Objectives The aims of the study were to characterize a large cohort of COVID-19-positive adult patients with AD and to identify predictors of COVID-19-associated hospitalization and mortality. Methods A population-based nested case-control study was performed. Multivariable logistic regression was used to evaluate odds ratios and 95% confidence intervals of predictors for COVID-19-associated hospitalization and mortality. Results Of 78,073 adult patients with AD, 3618 (4.6%) tested positive for COVID-19. Subclinical COVID-19 infection occurred in 3368 (93.1%) of COVID-19-positive patients, whereas 123 (3.4%), 46 (1.3%), 55 (1.5%), and 26 (0.7%) patients developed a mild, moderate, severe, and critical disease, respectively. Altogether, 250 patients (6.0%) were hospitalized, and 40 patients (1.1%) died because of COVID-19 complications. Coronavirus disease 2019-associated hospitalization was independently associated with the intake of extended courses of systemic corticosteroids (adjusted odds ratio, 1.96; 95% confidence interval, 1.23-3.14; P = 0.005). None of AD-related variables independently predicted COVID-19-associated mortality. The presence of comorbid metabolic syndrome, chronic obstructive pulmonary disease, chronic renal failure, and depression projected both COVID-19-associated hospitalization and mortality. Conclusions Prolonged systemic corticosteroids during the pandemic are associated with increased odds of COVID-19-associated hospitalization and should be avoided in patients with AD.

Original languageEnglish
Pages (from-to)S45-S52
Issue number1S
StatePublished - 1 Oct 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Lippincott Williams & Wilkins.


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • COVID-19/complications
  • Case-Control Studies
  • Cohort Studies
  • Cost of Illness
  • Dermatitis, Atopic/complications
  • Female
  • Hospitalization
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Survival Rate
  • Young Adult


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