The associations among improvement and alliance expectations, alliance during treatment, and treatment outcome for major depressive disorder

Jacques P. Barber, Sigal Zilcha-Mano, Robert Gallop, Marna Barrett, Kevin S. McCarthy, Ulrike Dinger

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To examine the associations between treatment/outcome expectations, alliance before and during treatment, and the impact of alliance on symptomatic improvement. Methods: One hundred and fifty-three depressed patients randomized to dynamic supportive-expressive psychotherapy (SET), antidepressant medication (ADM) or placebo (PBO) + clinical management completed ratings of treatment expectations, therapeutic alliance (CALPAS, WAI-S), and depressive symptoms (HAM-D). Results: Pretreatment expectations of the therapeutic alliance were significantly related to alliance later in therapy but did not differ across treatments and did not predict outcome. Alliance development over time differed between treatments; it increased more in SET than in PBO. After controlling for prior symptom improvement, early alliance predicted subsequent depression change. Conclusions: Expectations of alliance and of treatment outcome/improvement, measured prior to treatment onset, predicted subsequent alliance.

Original languageEnglish
Pages (from-to)257-268
Number of pages12
JournalPsychotherapy Research
Volume24
Issue number3
DOIs
StatePublished - May 2014
Externally publishedYes

Bibliographical note

Funding Information:
The original study was funded by a NIMH grant R01 MH 061410 to Jacques P. Barber. The sertraline and placebo pills were provided by a grant from Pfizer Corp. Neither sponsor had any role in the study besides funding the study (NIMH) or supplying the sertraline and placebo pills (Pfizer).

Keywords

  • alliance
  • depression
  • expectation
  • medication
  • placebo
  • psychodynamic psychotherapy

ASJC Scopus subject areas

  • Clinical Psychology

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