The association of insomnia with long COVID: An international collaborative study (ICOSS-II)

Si Jing Chen; Charles M. Morin; Hans Ivers; Yun Kwok Wing; Markku Partinen; Ilona Merikanto; Brigitte Holzinger; Colin A. Espie; Luigi De Gennaro; Yves Dauvilliers; Frances Chung; Juliana Yordanova; Domagoj Vidović; Catia Reis; Giuseppe Plazzi; Thomas Penzel; Michael R. Nadorff; Kentaro Matsui; Sergio Mota-Rolim; Damien Leger; Anne Marie Landtblom; Maria Korman; Yuichi Inoue; Harald Hrubos-Strøm; Ngan Yin Chan; Adrijana Koscec Bjelajac; Christian Benedict; Bjørn Bjorvatn

doi:10.1016/j.sleep.2023.09.034

The association of insomnia with long COVID: An international collaborative study (ICOSS-II)

Si Jing Chen, Charles M. Morin, Hans Ivers, Yun Kwok Wing, Markku Partinen, Ilona Merikanto, Brigitte Holzinger, Colin A. Espie, Luigi De Gennaro, Yves Dauvilliers, Frances Chung, Juliana Yordanova, Domagoj Vidović, Catia Reis, Giuseppe Plazzi, Thomas Penzel, Michael R. Nadorff, Kentaro Matsui, Sergio Mota-Rolim, Damien LegerAnne Marie Landtblom, Maria Korman, Yuichi Inoue, Harald Hrubos-Strøm, Ngan Yin Chan, Adrijana Koscec Bjelajac, Christian Benedict, Bjørn Bjorvatn

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection.

METHODS: Data were collected cross-sectionally (May-Dec 2021) as part of an international collaborative study involving participants from 16 countries. A total of 2311 participants (18-99 years old) with COVID-19 provided valid responses to a web-based survey about sleep, insomnia, and health-related variables. Log-binomial regression was used to assess bidirectional associations between insomnia and long COVID. Analyses were adjusted for age, sex, and health conditions, including sleep apnea, attention and memory problems, chronic fatigue, depression, and anxiety.

RESULTS: COVID-19 patients with pre-pandemic insomnia showed a higher risk of developing long COVID than those without pre-pandemic insomnia (70.8% vs 51.4%; adjusted relative risk [RR]: 1.33, 95% confidence interval [CI]: 1.07-1.65). Among COVID-19 cases without pre-pandemic insomnia, the rates of incident insomnia symptoms after infection were 24.1% for short COVID cases and 60.6% for long COVID cases (p < .001). Compared with short COVID cases, long COVID cases were associated with an increased risk of developing insomnia symptoms (adjusted RR: 2.00; 95% CI: 1.50-2.66).

CONCLUSIONS: The findings support a bidirectional relationship between insomnia and long COVID. These findings highlight the importance of addressing sleep and insomnia in the prevention and management of long COVID.

Original language	English
Pages (from-to)	216-222
Number of pages	7
Journal	Sleep Medicine
Volume	112
DOIs	https://doi.org/10.1016/j.sleep.2023.09.034
State	Published - Dec 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Anxiety/epidemiology
COVID-19/complications
Depression/diagnosis
Humans
Middle Aged
Post-Acute COVID-19 Syndrome
Sleep Initiation and Maintenance Disorders/epidemiology
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.sleep.2023.09.034

Cite this

Chen, S. J., Morin, C. M., Ivers, H., Wing, Y. K., Partinen, M., Merikanto, I., Holzinger, B., Espie, C. A., De Gennaro, L., Dauvilliers, Y., Chung, F., Yordanova, J., Vidović, D., Reis, C., Plazzi, G., Penzel, T., Nadorff, M. R., Matsui, K., Mota-Rolim, S., ... Bjorvatn, B. (2023). The association of insomnia with long COVID: An international collaborative study (ICOSS-II). Sleep Medicine, 112, 216-222. https://doi.org/10.1016/j.sleep.2023.09.034

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title = "The association of insomnia with long COVID: An international collaborative study (ICOSS-II)",

abstract = "OBJECTIVE: There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection.METHODS: Data were collected cross-sectionally (May-Dec 2021) as part of an international collaborative study involving participants from 16 countries. A total of 2311 participants (18-99 years old) with COVID-19 provided valid responses to a web-based survey about sleep, insomnia, and health-related variables. Log-binomial regression was used to assess bidirectional associations between insomnia and long COVID. Analyses were adjusted for age, sex, and health conditions, including sleep apnea, attention and memory problems, chronic fatigue, depression, and anxiety.RESULTS: COVID-19 patients with pre-pandemic insomnia showed a higher risk of developing long COVID than those without pre-pandemic insomnia (70.8% vs 51.4%; adjusted relative risk [RR]: 1.33, 95% confidence interval [CI]: 1.07-1.65). Among COVID-19 cases without pre-pandemic insomnia, the rates of incident insomnia symptoms after infection were 24.1% for short COVID cases and 60.6% for long COVID cases (p < .001). Compared with short COVID cases, long COVID cases were associated with an increased risk of developing insomnia symptoms (adjusted RR: 2.00; 95% CI: 1.50-2.66).CONCLUSIONS: The findings support a bidirectional relationship between insomnia and long COVID. These findings highlight the importance of addressing sleep and insomnia in the prevention and management of long COVID.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Anxiety/epidemiology, COVID-19/complications, Depression/diagnosis, Humans, Middle Aged, Post-Acute COVID-19 Syndrome, Sleep Initiation and Maintenance Disorders/epidemiology, Young Adult",

author = "Chen, {Si Jing} and Morin, {Charles M.} and Hans Ivers and Wing, {Yun Kwok} and Markku Partinen and Ilona Merikanto and Brigitte Holzinger and Espie, {Colin A.} and {De Gennaro}, Luigi and Yves Dauvilliers and Frances Chung and Juliana Yordanova and Domagoj Vidovi{\'c} and Catia Reis and Giuseppe Plazzi and Thomas Penzel and Nadorff, {Michael R.} and Kentaro Matsui and Sergio Mota-Rolim and Damien Leger and Landtblom, {Anne Marie} and Maria Korman and Yuichi Inoue and Harald Hrubos-Str{\o}m and Chan, {Ngan Yin} and Bjelajac, {Adrijana Koscec} and Christian Benedict and Bj{\o}rn Bjorvatn",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = dec,

doi = "10.1016/j.sleep.2023.09.034",

language = "English",

volume = "112",

pages = "216--222",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier",

}

Chen, SJ, Morin, CM, Ivers, H, Wing, YK, Partinen, M, Merikanto, I, Holzinger, B, Espie, CA, De Gennaro, L, Dauvilliers, Y, Chung, F, Yordanova, J, Vidović, D, Reis, C, Plazzi, G, Penzel, T, Nadorff, MR, Matsui, K, Mota-Rolim, S, Leger, D, Landtblom, AM, Korman, M, Inoue, Y, Hrubos-Strøm, H, Chan, NY, Bjelajac, AK, Benedict, C & Bjorvatn, B 2023, 'The association of insomnia with long COVID: An international collaborative study (ICOSS-II)', Sleep Medicine, vol. 112, pp. 216-222. https://doi.org/10.1016/j.sleep.2023.09.034

TY - JOUR

T1 - The association of insomnia with long COVID

T2 - An international collaborative study (ICOSS-II)

AU - Chen, Si Jing

AU - Morin, Charles M.

AU - Ivers, Hans

AU - Wing, Yun Kwok

AU - Partinen, Markku

AU - Merikanto, Ilona

AU - Holzinger, Brigitte

AU - Espie, Colin A.

AU - De Gennaro, Luigi

AU - Dauvilliers, Yves

AU - Chung, Frances

AU - Yordanova, Juliana

AU - Vidović, Domagoj

AU - Reis, Catia

AU - Plazzi, Giuseppe

AU - Penzel, Thomas

AU - Nadorff, Michael R.

AU - Matsui, Kentaro

AU - Mota-Rolim, Sergio

AU - Leger, Damien

AU - Landtblom, Anne Marie

AU - Korman, Maria

AU - Inoue, Yuichi

AU - Hrubos-Strøm, Harald

AU - Chan, Ngan Yin

AU - Bjelajac, Adrijana Koscec

AU - Benedict, Christian

AU - Bjorvatn, Bjørn

PY - 2023/12

Y1 - 2023/12

N2 - OBJECTIVE: There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection.METHODS: Data were collected cross-sectionally (May-Dec 2021) as part of an international collaborative study involving participants from 16 countries. A total of 2311 participants (18-99 years old) with COVID-19 provided valid responses to a web-based survey about sleep, insomnia, and health-related variables. Log-binomial regression was used to assess bidirectional associations between insomnia and long COVID. Analyses were adjusted for age, sex, and health conditions, including sleep apnea, attention and memory problems, chronic fatigue, depression, and anxiety.RESULTS: COVID-19 patients with pre-pandemic insomnia showed a higher risk of developing long COVID than those without pre-pandemic insomnia (70.8% vs 51.4%; adjusted relative risk [RR]: 1.33, 95% confidence interval [CI]: 1.07-1.65). Among COVID-19 cases without pre-pandemic insomnia, the rates of incident insomnia symptoms after infection were 24.1% for short COVID cases and 60.6% for long COVID cases (p < .001). Compared with short COVID cases, long COVID cases were associated with an increased risk of developing insomnia symptoms (adjusted RR: 2.00; 95% CI: 1.50-2.66).CONCLUSIONS: The findings support a bidirectional relationship between insomnia and long COVID. These findings highlight the importance of addressing sleep and insomnia in the prevention and management of long COVID.

AB - OBJECTIVE: There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection.METHODS: Data were collected cross-sectionally (May-Dec 2021) as part of an international collaborative study involving participants from 16 countries. A total of 2311 participants (18-99 years old) with COVID-19 provided valid responses to a web-based survey about sleep, insomnia, and health-related variables. Log-binomial regression was used to assess bidirectional associations between insomnia and long COVID. Analyses were adjusted for age, sex, and health conditions, including sleep apnea, attention and memory problems, chronic fatigue, depression, and anxiety.RESULTS: COVID-19 patients with pre-pandemic insomnia showed a higher risk of developing long COVID than those without pre-pandemic insomnia (70.8% vs 51.4%; adjusted relative risk [RR]: 1.33, 95% confidence interval [CI]: 1.07-1.65). Among COVID-19 cases without pre-pandemic insomnia, the rates of incident insomnia symptoms after infection were 24.1% for short COVID cases and 60.6% for long COVID cases (p < .001). Compared with short COVID cases, long COVID cases were associated with an increased risk of developing insomnia symptoms (adjusted RR: 2.00; 95% CI: 1.50-2.66).CONCLUSIONS: The findings support a bidirectional relationship between insomnia and long COVID. These findings highlight the importance of addressing sleep and insomnia in the prevention and management of long COVID.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anxiety/epidemiology

KW - COVID-19/complications

KW - Depression/diagnosis

KW - Humans

KW - Middle Aged

KW - Post-Acute COVID-19 Syndrome

KW - Sleep Initiation and Maintenance Disorders/epidemiology

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85175301793&partnerID=8YFLogxK

U2 - 10.1016/j.sleep.2023.09.034

DO - 10.1016/j.sleep.2023.09.034

M3 - Article

C2 - 37922783

AN - SCOPUS:85175301793

SN - 1389-9457

VL - 112

SP - 216

EP - 222

JO - Sleep Medicine

JF - Sleep Medicine

ER -

The association of insomnia with long COVID: An international collaborative study (ICOSS-II)

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this