The ARTS connection: Role of ARTS in apoptosis and cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

ARTS is an unusual septin that is localized to mitochondria in living cells and promotes apoptosis by antagonizing IAPs. ARTS functions as a tumor suppressor in Acute Lymphoblatic Leukemia (ALL) and is lost in more than 70% of leukemic patients. The loss of ARTS is specific as levels of H5, a closely related non-apoptotic septin protein derived from the same gene, were unaffected. Thus, ARTS, a new member in the mitochondrial proapoptotic arsenal, provides a link between mitoohondria, apoptosis and cancer.

Original languageEnglish
Pages (from-to)1019-1021
Number of pages3
JournalCell Cycle
Volume3
Issue number8
DOIs
StatePublished - Aug 2004
Externally publishedYes

Keywords

  • ARTS
  • Apoptosis
  • Cancer
  • Caspase
  • IAP
  • Mitochondria
  • Tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

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