The ARTS connection: Role of ARTS in apoptosis and cancer

Sarit Larisch

doi:10.4161/cc.3.8.1021

The ARTS connection: Role of ARTS in apoptosis and cancer

Research output: Contribution to journal › Review article › peer-review

Abstract

ARTS is an unusual septin that is localized to mitochondria in living cells and promotes apoptosis by antagonizing IAPs. ARTS functions as a tumor suppressor in Acute Lymphoblatic Leukemia (ALL) and is lost in more than 70% of leukemic patients. The loss of ARTS is specific as levels of H5, a closely related non-apoptotic septin protein derived from the same gene, were unaffected. Thus, ARTS, a new member in the mitochondrial proapoptotic arsenal, provides a link between mitoohondria, apoptosis and cancer.

Original language	English
Pages (from-to)	1019-1021
Number of pages	3
Journal	Cell Cycle
Volume	3
Issue number	8
DOIs	https://doi.org/10.4161/cc.3.8.1021
State	Published - Aug 2004
Externally published	Yes

Keywords

ARTS
Apoptosis
Cancer
Caspase
IAP
Mitochondria
Tumor suppressor

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/cc.3.8.1021

Cite this

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abstract = "ARTS is an unusual septin that is localized to mitochondria in living cells and promotes apoptosis by antagonizing IAPs. ARTS functions as a tumor suppressor in Acute Lymphoblatic Leukemia (ALL) and is lost in more than 70% of leukemic patients. The loss of ARTS is specific as levels of H5, a closely related non-apoptotic septin protein derived from the same gene, were unaffected. Thus, ARTS, a new member in the mitochondrial proapoptotic arsenal, provides a link between mitoohondria, apoptosis and cancer.",

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AB - ARTS is an unusual septin that is localized to mitochondria in living cells and promotes apoptosis by antagonizing IAPs. ARTS functions as a tumor suppressor in Acute Lymphoblatic Leukemia (ALL) and is lost in more than 70% of leukemic patients. The loss of ARTS is specific as levels of H5, a closely related non-apoptotic septin protein derived from the same gene, were unaffected. Thus, ARTS, a new member in the mitochondrial proapoptotic arsenal, provides a link between mitoohondria, apoptosis and cancer.

KW - ARTS

KW - Apoptosis

KW - Cancer

KW - Caspase

KW - IAP

KW - Mitochondria

KW - Tumor suppressor

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JO - Cell Cycle

JF - Cell Cycle

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ER -

The ARTS connection: Role of ARTS in apoptosis and cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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