The anorexic potency of drugs is differentially influenced in various rat models of feeding

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Abstract

The anorexic potency of fenfluramine (2.25-7.5 mg/kg), mazindol (0.1-3.0 mg/kg) and naloxone (0.25-2.25 mg/kg) was compared in 3 groups of rats. Group 1 had bilateral ventromedial hypothalamic lesions (VMH), group 2 received salami supplement to their diet (salami), group 3 received standard lab chow only (standard). One hour intakes of sweetened chow mash were compared. Rats were undeprived. Fenfluramine did not reduce feeding in salami rats (all doses) but caused similar anorexia in the other 2 groups. Mazindol induced equivalent anorexia in all groups. Naloxone anorexia at low doses was milder in VMH rats and followed a V-shaped dose response in the other 2 groups. The results indicate that the anorexic potency of particular drugs may be differentially dependent on feeding variables.

Original languageEnglish
Pages (from-to)111
Number of pages1
JournalIRCS Medical Science
Volume9
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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