The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

Hazem Safory; Samah Neame; Yoav Shulman; Salman Zubedat; Inna Radzishevsky; Dina Rosenberg; Hagit Sason; Simone Engelender; Avi Avital; Swen Hülsmann; Jackie Schiller; Herman Wolosker

doi:10.15252/embr.201439561

The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

Hazem Safory
, Samah Neame
, Yoav Shulman
, Salman Zubedat
, Inna Radzishevsky
, Dina Rosenberg
, Hagit Sason
, Simone Engelender
, Avi Avital
, Swen Hülsmann
, Jackie Schiller
, Herman Wolosker

Research output: Contribution to journal › Article › peer-review

Abstract

Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders.

Original language	English
Pages (from-to)	590-598
Number of pages	9
Journal	EMBO Reports
Volume	16
Issue number	5
DOIs	https://doi.org/10.15252/embr.201439561
State	Published - 1 May 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 The Authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

D-serine
GlyT2
glycine receptor
hyperekplexia
non-ketotic hyperglycinemia

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.15252/embr.201439561

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Safory, H., Neame, S., Shulman, Y., Zubedat, S., Radzishevsky, I., Rosenberg, D., Sason, H., Engelender, S., Avital, A., Hülsmann, S., Schiller, J., & Wolosker, H. (2015). The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission. EMBO Reports, 16(5), 590-598. https://doi.org/10.15252/embr.201439561

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title = "The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission",

abstract = "Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders.",

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author = "Hazem Safory and Samah Neame and Yoav Shulman and Salman Zubedat and Inna Radzishevsky and Dina Rosenberg and Hagit Sason and Simone Engelender and Avi Avital and Swen H{\"u}lsmann and Jackie Schiller and Herman Wolosker",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = may,

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doi = "10.15252/embr.201439561",

language = "English",

volume = "16",

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Safory, H, Neame, S, Shulman, Y, Zubedat, S, Radzishevsky, I, Rosenberg, D, Sason, H, Engelender, S, Avital, A, Hülsmann, S, Schiller, J & Wolosker, H 2015, 'The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission', EMBO Reports, vol. 16, no. 5, pp. 590-598. https://doi.org/10.15252/embr.201439561

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T1 - The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

AU - Safory, Hazem

AU - Neame, Samah

AU - Shulman, Yoav

AU - Zubedat, Salman

AU - Radzishevsky, Inna

AU - Rosenberg, Dina

AU - Sason, Hagit

AU - Engelender, Simone

AU - Avital, Avi

AU - Hülsmann, Swen

AU - Schiller, Jackie

AU - Wolosker, Herman

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders.

AB - Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders.

KW - D-serine

KW - GlyT2

KW - glycine receptor

KW - hyperekplexia

KW - non-ketotic hyperglycinemia

UR - https://www.scopus.com/pages/publications/84928926220

U2 - 10.15252/embr.201439561

DO - 10.15252/embr.201439561

M3 - Article

C2 - 25755256

AN - SCOPUS:84928926220

SN - 1469-221X

VL - 16

SP - 590

EP - 598

JO - EMBO Reports

JF - EMBO Reports

IS - 5

ER -

The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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