Territorial blueprint in the hippocampal system

Sylvia Wirth; Amelie Soumier; Marina Eliava; Dori Derdikman; Shlomo Wagner; Valery Grinevich; Angela Sirigu

doi:10.1016/j.tics.2021.06.005

Territorial blueprint in the hippocampal system

Sylvia Wirth, Amelie Soumier, Marina Eliava, Dori Derdikman, Shlomo Wagner, Valery Grinevich, Angela Sirigu

Department of Neurobiology

Research output: Contribution to journal › Review article › peer-review

Abstract

As we skillfully navigate through familiar places, neural computations of distances and coordinates escape our attention. However, we perceive clearly the division of space into socially meaningful territories. ‘My space’ versus ‘your space’ is a distinction familiar to all of us. Spatial frontiers are social in nature since they regulate individuals’ access to utilities in space depending on hierarchy and affiliation. How does the brain integrate spatial geometry with social territory? We propose that the action of oxytocin (OT) in the entorhinal–hippocampal regions supports this process. Grounded on the functional role of the hypothalamic neuropeptide in the hippocampal system, we show how OT-induced plasticity may bias the geometrical coding of place and grid cells to represent social territories.

Original language	English
Pages (from-to)	831-842
Number of pages	12
Journal	Trends in Cognitive Sciences
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.tics.2021.06.005
State	Published - Oct 2021

Bibliographical note

Funding Information:
A. Sirigu, A. Soumier, and S.Wirth are supported by CNRS , ANR ( 16-CE37-0017-01 , 17-CE37-0015-01 ), and a Labex Cortex ( ANR-11–LABEX-0042 ) grant from the University of Lyon I in the program ‘Investissement d’Avenir’. V.G. is supported by German Research Foundation (DFG) Collaborative Research Center (SFB) 1158-2 , DFG-RSF grant GR 3619/15-1 , DFG grant GR 3619/10-1 , DFG grant GR 3619/13-1 , and DFG-SNSF grant GR 3619/8-1 . D. Derdikman is supported by German-Israeli Foundation for Scientific Research and Development , by a CRCNS US-Israel NIMH-BSF grant ( 1R01 MH125544-01 ) and by a Rappaport Institute grant. S. Wagner is supported by the Israel Science Foundation (ISF grants # 1361/17 ), a binational joint program of the Ministry of Europe and Foreign Affairs (MEAE) and the Ministry of Higher Education, Research and Innovation (MESRI) of France and the Ministry of Science and Technology of Israel (grant # 3-16545 ) the Ministry of Science, Technology and Space of Israel (Grant # 3-12068 ) and the United States-Israel Binational Science Foundation (BSF grant # 2019186 ). We thank Dr Thomas Splettstoesser (SciStyle; https://www.scistyle.com ) for his help with the preparation of figures and Alessandro Treves for exciting discussion.

Funding Information:
A. Sirigu, A. Soumier, and S.Wirth are supported by CNRS, ANR (16-CE37-0017-01, 17-CE37-0015-01), and a Labex Cortex (ANR-11?LABEX-0042) grant from the University of Lyon I in the program ?Investissement d'Avenir?. V.G. is supported by German Research Foundation (DFG) Collaborative Research Center (SFB) 1158-2, DFG-RSF grant GR 3619/15-1, DFG grant GR 3619/10-1, DFG grant GR 3619/13-1, and DFG-SNSF grant GR 3619/8-1. D. Derdikman is supported by German-Israeli Foundation for Scientific Research and Development, by a CRCNS US-Israel NIMH-BSF grant (1R01 MH125544-01) and by a Rappaport Institute grant. S. Wagner is supported by the Israel Science Foundation (ISF grants #1361/17), a binational joint program of the Ministry of Europe and Foreign Affairs (MEAE) and the Ministry of Higher Education, Research and Innovation (MESRI) of France and the Ministry of Science and Technology of Israel (grant #3-16545) the Ministry of Science, Technology and Space of Israel (Grant #3-12068) and the United States-Israel Binational Science Foundation (BSF grant #2019186). We thank Dr Thomas Splettstoesser (SciStyle; https://www.scistyle.com) for his help with the preparation of figures and Alessandro Treves for exciting discussion. S. Wirth, V.G. and A. Sirigu proposed the original concept framework. All authors contributed to the elaboration of the proposed model. S. Wirth wrote a first draft and A. Sirigu and V.G. provided ongoing review. All authors contributed to and approved the final version of the document. The authors have no interests to declare.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

hippocampus
oxytocin
resource protection
social competition
space
territorial behavior

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Experimental and Cognitive Psychology
Cognitive Neuroscience

Access to Document

10.1016/j.tics.2021.06.005

Cite this

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title = "Territorial blueprint in the hippocampal system",

abstract = "As we skillfully navigate through familiar places, neural computations of distances and coordinates escape our attention. However, we perceive clearly the division of space into socially meaningful territories. {\textquoteleft}My space{\textquoteright} versus {\textquoteleft}your space{\textquoteright} is a distinction familiar to all of us. Spatial frontiers are social in nature since they regulate individuals{\textquoteright} access to utilities in space depending on hierarchy and affiliation. How does the brain integrate spatial geometry with social territory? We propose that the action of oxytocin (OT) in the entorhinal–hippocampal regions supports this process. Grounded on the functional role of the hypothalamic neuropeptide in the hippocampal system, we show how OT-induced plasticity may bias the geometrical coding of place and grid cells to represent social territories.",

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note = "Funding Information: A. Sirigu, A. Soumier, and S.Wirth are supported by CNRS , ANR ( 16-CE37-0017-01 , 17-CE37-0015-01 ), and a Labex Cortex ( ANR-11–LABEX-0042 ) grant from the University of Lyon I in the program {\textquoteleft}Investissement d{\textquoteright}Avenir{\textquoteright}. V.G. is supported by German Research Foundation (DFG) Collaborative Research Center (SFB) 1158-2 , DFG-RSF grant GR 3619/15-1 , DFG grant GR 3619/10-1 , DFG grant GR 3619/13-1 , and DFG-SNSF grant GR 3619/8-1 . D. Derdikman is supported by German-Israeli Foundation for Scientific Research and Development , by a CRCNS US-Israel NIMH-BSF grant ( 1R01 MH125544-01 ) and by a Rappaport Institute grant. S. Wagner is supported by the Israel Science Foundation (ISF grants # 1361/17 ), a binational joint program of the Ministry of Europe and Foreign Affairs (MEAE) and the Ministry of Higher Education, Research and Innovation (MESRI) of France and the Ministry of Science and Technology of Israel (grant # 3-16545 ) the Ministry of Science, Technology and Space of Israel (Grant # 3-12068 ) and the United States-Israel Binational Science Foundation (BSF grant # 2019186 ). We thank Dr Thomas Splettstoesser (SciStyle; https://www.scistyle.com ) for his help with the preparation of figures and Alessandro Treves for exciting discussion. Funding Information: A. Sirigu, A. Soumier, and S.Wirth are supported by CNRS, ANR (16-CE37-0017-01, 17-CE37-0015-01), and a Labex Cortex (ANR-11?LABEX-0042) grant from the University of Lyon I in the program ?Investissement d'Avenir?. V.G. is supported by German Research Foundation (DFG) Collaborative Research Center (SFB) 1158-2, DFG-RSF grant GR 3619/15-1, DFG grant GR 3619/10-1, DFG grant GR 3619/13-1, and DFG-SNSF grant GR 3619/8-1. D. Derdikman is supported by German-Israeli Foundation for Scientific Research and Development, by a CRCNS US-Israel NIMH-BSF grant (1R01 MH125544-01) and by a Rappaport Institute grant. S. Wagner is supported by the Israel Science Foundation (ISF grants #1361/17), a binational joint program of the Ministry of Europe and Foreign Affairs (MEAE) and the Ministry of Higher Education, Research and Innovation (MESRI) of France and the Ministry of Science and Technology of Israel (grant #3-16545) the Ministry of Science, Technology and Space of Israel (Grant #3-12068) and the United States-Israel Binational Science Foundation (BSF grant #2019186). We thank Dr Thomas Splettstoesser (SciStyle; https://www.scistyle.com) for his help with the preparation of figures and Alessandro Treves for exciting discussion. S. Wirth, V.G. and A. Sirigu proposed the original concept framework. All authors contributed to the elaboration of the proposed model. S. Wirth wrote a first draft and A. Sirigu and V.G. provided ongoing review. All authors contributed to and approved the final version of the document. The authors have no interests to declare. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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AU - Wagner, Shlomo

AU - Grinevich, Valery

AU - Sirigu, Angela

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Territorial blueprint in the hippocampal system

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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