Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic

Yan Wang; Tahilin Sanchez Karver; Carla J. Berg; Clare Barrington; Yeycy Donastorg; Martha Perez; Hoisex Gomez; Wendy Davis; Noya Galai; Deanna Kerrigan

doi:10.1007/s10461-022-03940-x

Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic

Yan Wang, Tahilin Sanchez Karver, Carla J. Berg, Clare Barrington, Yeycy Donastorg, Martha Perez, Hoisex Gomez, Wendy Davis, Noya Galai, Deanna Kerrigan

Department of Statistics

Research output: Contribution to journal › Article › peer-review

Abstract

Female sex workers (FSW) have worse HIV outcomes in part due to lower anti-retroviral therapy (ART) adherence. Substance use and depression are important barriers to ART adherence, yet few studies have assessed these relationships among FSW in longitudinal studies. Cross-Lagged Panel Models and autoregressive mediation analyses assessed substance use (illicit drug use and alcohol use disorders) in relation to ART non-adherence and the mediation role of depressive symptoms among 240 FSW living with HIV in the Dominican Republic. In annual visits (T1, T2, T3), the majority (70%, 66%, and 53%) reported at-risk drinking and 15%, 13% and 9% used illicit drug during the past 6 months. Most FSW (70%, 62% and 46%) had mild-to-severe depression. Illicit drug use predicted later ART non-adherence. This relationship was not mediated via depressive symptoms. Integrated substance use and HIV care interventions are needed to promote ART adherence and viral suppression among FSW.

Original language	English
Number of pages	10
Journal	AIDS and Behavior
Volume	27
Issue number	7
DOIs	https://doi.org/10.1007/s10461-022-03940-x
State	Published - Jul 2023

Bibliographical note

Funding Information:
This study was supported with an R01 Grant awarded by the U.S. National Institute of Mental Health (R01MH110158, PI: D. Kerrigan) and a pilot award (PI: Y. Wang) awarded by the District of Columbia Center for AIDS Research, an NIH funded program (P30AI117970) supported by NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, NIDDK, NIMHD, NIDCR, NINR, FIC and OAR.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

ART adherence
Depression
HIV
Sex work
Substance use

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10461-022-03940-x

Cite this

@article{db4c65a876d948c489a8276cfd26afa3,

title = "Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic",

abstract = "Female sex workers (FSW) have worse HIV outcomes in part due to lower anti-retroviral therapy (ART) adherence. Substance use and depression are important barriers to ART adherence, yet few studies have assessed these relationships among FSW in longitudinal studies. Cross-Lagged Panel Models and autoregressive mediation analyses assessed substance use (illicit drug use and alcohol use disorders) in relation to ART non-adherence and the mediation role of depressive symptoms among 240 FSW living with HIV in the Dominican Republic. In annual visits (T1, T2, T3), the majority (70%, 66%, and 53%) reported at-risk drinking and 15%, 13% and 9% used illicit drug during the past 6 months. Most FSW (70%, 62% and 46%) had mild-to-severe depression. Illicit drug use predicted later ART non-adherence. This relationship was not mediated via depressive symptoms. Integrated substance use and HIV care interventions are needed to promote ART adherence and viral suppression among FSW.",

keywords = "ART adherence, Depression, HIV, Sex work, Substance use",

author = "Yan Wang and Karver, {Tahilin Sanchez} and Berg, {Carla J.} and Clare Barrington and Yeycy Donastorg and Martha Perez and Hoisex Gomez and Wendy Davis and Noya Galai and Deanna Kerrigan",

note = "Funding Information: This study was supported with an R01 Grant awarded by the U.S. National Institute of Mental Health (R01MH110158, PI: D. Kerrigan) and a pilot award (PI: Y. Wang) awarded by the District of Columbia Center for AIDS Research, an NIH funded program (P30AI117970) supported by NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, NIDDK, NIMHD, NIDCR, NINR, FIC and OAR. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

month = jul,

doi = "10.1007/s10461-022-03940-x",

language = "English",

volume = "27",

journal = "AIDS and Behavior",

issn = "1090-7165",

publisher = "Springer New York",

number = "7",

}

TY - JOUR

T1 - Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic

AU - Wang, Yan

AU - Karver, Tahilin Sanchez

AU - Berg, Carla J.

AU - Barrington, Clare

AU - Donastorg, Yeycy

AU - Perez, Martha

AU - Gomez, Hoisex

AU - Davis, Wendy

AU - Galai, Noya

AU - Kerrigan, Deanna

N1 - Funding Information: This study was supported with an R01 Grant awarded by the U.S. National Institute of Mental Health (R01MH110158, PI: D. Kerrigan) and a pilot award (PI: Y. Wang) awarded by the District of Columbia Center for AIDS Research, an NIH funded program (P30AI117970) supported by NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, NIDDK, NIMHD, NIDCR, NINR, FIC and OAR. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2023/7

Y1 - 2023/7

N2 - Female sex workers (FSW) have worse HIV outcomes in part due to lower anti-retroviral therapy (ART) adherence. Substance use and depression are important barriers to ART adherence, yet few studies have assessed these relationships among FSW in longitudinal studies. Cross-Lagged Panel Models and autoregressive mediation analyses assessed substance use (illicit drug use and alcohol use disorders) in relation to ART non-adherence and the mediation role of depressive symptoms among 240 FSW living with HIV in the Dominican Republic. In annual visits (T1, T2, T3), the majority (70%, 66%, and 53%) reported at-risk drinking and 15%, 13% and 9% used illicit drug during the past 6 months. Most FSW (70%, 62% and 46%) had mild-to-severe depression. Illicit drug use predicted later ART non-adherence. This relationship was not mediated via depressive symptoms. Integrated substance use and HIV care interventions are needed to promote ART adherence and viral suppression among FSW.

AB - Female sex workers (FSW) have worse HIV outcomes in part due to lower anti-retroviral therapy (ART) adherence. Substance use and depression are important barriers to ART adherence, yet few studies have assessed these relationships among FSW in longitudinal studies. Cross-Lagged Panel Models and autoregressive mediation analyses assessed substance use (illicit drug use and alcohol use disorders) in relation to ART non-adherence and the mediation role of depressive symptoms among 240 FSW living with HIV in the Dominican Republic. In annual visits (T1, T2, T3), the majority (70%, 66%, and 53%) reported at-risk drinking and 15%, 13% and 9% used illicit drug during the past 6 months. Most FSW (70%, 62% and 46%) had mild-to-severe depression. Illicit drug use predicted later ART non-adherence. This relationship was not mediated via depressive symptoms. Integrated substance use and HIV care interventions are needed to promote ART adherence and viral suppression among FSW.

KW - ART adherence

KW - Depression

KW - HIV

KW - Sex work

KW - Substance use

UR - http://www.scopus.com/inward/record.url?scp=85143493923&partnerID=8YFLogxK

U2 - 10.1007/s10461-022-03940-x

DO - 10.1007/s10461-022-03940-x

M3 - Article

AN - SCOPUS:85143493923

SN - 1090-7165

VL - 27

JO - AIDS and Behavior

JF - AIDS and Behavior

IS - 7

ER -

Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this