Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): Study protocol 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sciences 1103 Clinical Sciences

Avital Hirsch, Mark A. Katz, Alon Laufer Peretz, David Greenberg, Rachael Wendlandt, Yonat Shemer Avni, Gabriella Newes-Adeyi, Ilan Gofer, Maya Leventer-Roberts, Nadav Davidovitch, Anat Rosenthal, Rachel Gur-Arie, Tomer Hertz, Aharona Glatman-Freedman, Arnold S. Monto, Eduardo Azziz-Baumgartner, Jill Morris Ferdinands, Emily Toth Martin, Ryan E. Malosh, Joan Manuel Neyra QuijandríaMin Levine, William Campbell, Ran Balicer, Mark G. Thompson

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI) prospectively follows a cohort of healthcare personnel (HCP) in two hospitals in Israel. SHIRI will describe the frequency of influenza virus infections among HCP, identify predictors of vaccine acceptance, examine how repeated influenza vaccination may modify immunogenicity, and evaluate influenza vaccine effectiveness in preventing influenza illness and missed work. Methods: Cohort enrollment began in October, 2016; a second year of the study and a second wave of cohort enrollment began in June 2017. The study will run for at least 3 years and will follow approximately 2000 HCP (who are both employees and members of Clalit Health Services [CHS]) with routine direct patient contact. Eligible HCP are recruited using a stratified sampling strategy. After informed consent, participants complete a brief enrollment survey with questions about occupational responsibilities and knowledge, attitudes, and practices about influenza vaccines. Blood samples are collected at enrollment and at the end of influenza season; HCP who choose to be vaccinated contribute additional blood one month after vaccination. During the influenza season, participants receive twice-weekly short message service (SMS) messages asking them if they have acute respiratory illness or febrile illness (ARFI) symptoms. Ill participants receive follow-up SMS messages to confirm illness symptoms and duration and are asked to self-collect a nasal swab. Information on socio-economic characteristics, current and past medical conditions, medical care utilization and vaccination history is extracted from the CHS database. Information about missed work due to illness is obtained by self-report and from employee records. Respiratory specimens from self-collected nasal swabs are tested for influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, and coronaviruses using validated multiplex quantitative real-time reverse transcription polymerase chain reaction assays. The hemagglutination inhibition assay will be used to detect the presence of neutralizing influenza antibodies in serum. Discussion: SHIRI will expand our knowledge of the burden of respiratory viral infections among HCP and the effectiveness of current and repeated annual influenza vaccination in preventing influenza illness, medical utilization, and missed workdays among HCP who are in direct contact with patients. Trial registration: NCT03331991. Registered on November 6, 2017.

Original languageEnglish
Article number550
JournalBMC Infectious Diseases
Volume18
Issue number1
DOIs
StatePublished - 6 Nov 2018
Externally publishedYes

Bibliographical note

Funding Information:
This prospective cohort study of influenza vaccine effectiveness in HCP is funded by the United States Centers for Disease Control and Prevention (US CDC). A steering committee, consisting of principal investigators from the two hospitals, Clalit Health Services (CHS), the Israeli Center for Disease Control, Abt Associates, and the US CDC was established and charged with making critical decisions related to the study. Additional investigators from the University of Michigan School of Public Health and the Ben Gurion University School of Public Health will advise on laboratory methods and qualitative methods related to the study. Study activities are described in Fig. 1.

Publisher Copyright:
© 2018 The Author(s).

ASJC Scopus subject areas

  • Infectious Diseases

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