Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro: Possible inhibitory effect on oestradiol secretion

Eytan R. Barnea; Fuad Fares; Kol Shahar

doi:10.1016/0143-4004(89)90004-0

Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro: Possible inhibitory effect on oestradiol secretion

Eytan R. Barnea
, Fuad Fares
, Kol Shahar

Research output: Contribution to journal › Article › peer-review

Abstract

Maternal and fetal circulating prolactin (PRL) increases 10-fold compared with the non-pregnant state. We examined the effect of PRL upon placental steroidogenesis. It had a significant (P < 0.05) time-dependent stimulatory effect upon placental explants/P₄ accumulation and secretion into the medium. The maximal stimulatory effect (two-fold) in dose-dependent experiments was found to be 200 ng/ml. The effect of PRL upon oestradiol secretion was mainly inhibitory. This inhibition was most pronounced at 200 ng/ml. In conclusion, placental steroid secretion is modulated by PRL. This effect occurs mainly at concentrations seen in the placenta at term, suggestive of its physiologic role.

Original language	English
Pages (from-to)	37-43
Number of pages	7
Journal	Placenta
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0143-4004(89)90004-0
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1016/0143-4004(89)90004-0

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title = "Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro: Possible inhibitory effect on oestradiol secretion",

abstract = "Maternal and fetal circulating prolactin (PRL) increases 10-fold compared with the non-pregnant state. We examined the effect of PRL upon placental steroidogenesis. It had a significant (P < 0.05) time-dependent stimulatory effect upon placental explants/P4 accumulation and secretion into the medium. The maximal stimulatory effect (two-fold) in dose-dependent experiments was found to be 200 ng/ml. The effect of PRL upon oestradiol secretion was mainly inhibitory. This inhibition was most pronounced at 200 ng/ml. In conclusion, placental steroid secretion is modulated by PRL. This effect occurs mainly at concentrations seen in the placenta at term, suggestive of its physiologic role.",

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doi = "10.1016/0143-4004(89)90004-0",

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T1 - Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro

T2 - Possible inhibitory effect on oestradiol secretion

AU - Barnea, Eytan R.

AU - Fares, Fuad

AU - Shahar, Kol

PY - 1989

Y1 - 1989

N2 - Maternal and fetal circulating prolactin (PRL) increases 10-fold compared with the non-pregnant state. We examined the effect of PRL upon placental steroidogenesis. It had a significant (P < 0.05) time-dependent stimulatory effect upon placental explants/P4 accumulation and secretion into the medium. The maximal stimulatory effect (two-fold) in dose-dependent experiments was found to be 200 ng/ml. The effect of PRL upon oestradiol secretion was mainly inhibitory. This inhibition was most pronounced at 200 ng/ml. In conclusion, placental steroid secretion is modulated by PRL. This effect occurs mainly at concentrations seen in the placenta at term, suggestive of its physiologic role.

AB - Maternal and fetal circulating prolactin (PRL) increases 10-fold compared with the non-pregnant state. We examined the effect of PRL upon placental steroidogenesis. It had a significant (P < 0.05) time-dependent stimulatory effect upon placental explants/P4 accumulation and secretion into the medium. The maximal stimulatory effect (two-fold) in dose-dependent experiments was found to be 200 ng/ml. The effect of PRL upon oestradiol secretion was mainly inhibitory. This inhibition was most pronounced at 200 ng/ml. In conclusion, placental steroid secretion is modulated by PRL. This effect occurs mainly at concentrations seen in the placenta at term, suggestive of its physiologic role.

UR - https://www.scopus.com/pages/publications/0024524658

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AN - SCOPUS:0024524658

SN - 0143-4004

VL - 10

SP - 37

EP - 43

JO - Placenta

JF - Placenta

IS - 1

ER -

Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro: Possible inhibitory effect on oestradiol secretion

Abstract

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