Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro: Possible inhibitory effect on oestradiol secretion

Eytan R. Barnea, Fuad Fares, Kol Shahar

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal and fetal circulating prolactin (PRL) increases 10-fold compared with the non-pregnant state. We examined the effect of PRL upon placental steroidogenesis. It had a significant (P < 0.05) time-dependent stimulatory effect upon placental explants/P4 accumulation and secretion into the medium. The maximal stimulatory effect (two-fold) in dose-dependent experiments was found to be 200 ng/ml. The effect of PRL upon oestradiol secretion was mainly inhibitory. This inhibition was most pronounced at 200 ng/ml. In conclusion, placental steroid secretion is modulated by PRL. This effect occurs mainly at concentrations seen in the placenta at term, suggestive of its physiologic role.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalPlacenta
Volume10
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro: Possible inhibitory effect on oestradiol secretion'. Together they form a unique fingerprint.

Cite this