TY - GEN
T1 - Spike sorting
T2 - 18th Annual Conference on Neural Information Processing Systems, NIPS 2004
AU - Bar-Hillel, Aharon
AU - Spiro, Adam
AU - Stark, Eran
PY - 2005
Y1 - 2005
N2 - Spike sorting involves clustering spike trains recorded by a microelectrode according to the source neuron. It is a complicated problem, which requires a lot of human labor, partly due to the non-stationary nature of the data. We propose an automated technique for the clustering of non-stationary Gaussian sources in a Bayesian framework. At a first search stage, data is divided into short time frames and candidate descriptions of the data as a mixture of Gaussians are computed for each frame. At a second stage transition probabilities between candidate mixtures are computed, and a globally optimal clustering is found as the MAP solution of the resulting probabilistic model. Transition probabilities are computed using local stationarity assumptions and are based on a Gaussian version of the Jensen-Shannon divergence. The method was applied to several recordings. The performance appeared almost indistinguishable from humans in a wide range of scenarios, including movement, merges, and splits of clusters.
AB - Spike sorting involves clustering spike trains recorded by a microelectrode according to the source neuron. It is a complicated problem, which requires a lot of human labor, partly due to the non-stationary nature of the data. We propose an automated technique for the clustering of non-stationary Gaussian sources in a Bayesian framework. At a first search stage, data is divided into short time frames and candidate descriptions of the data as a mixture of Gaussians are computed for each frame. At a second stage transition probabilities between candidate mixtures are computed, and a globally optimal clustering is found as the MAP solution of the resulting probabilistic model. Transition probabilities are computed using local stationarity assumptions and are based on a Gaussian version of the Jensen-Shannon divergence. The method was applied to several recordings. The performance appeared almost indistinguishable from humans in a wide range of scenarios, including movement, merges, and splits of clusters.
UR - http://www.scopus.com/inward/record.url?scp=37749005108&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:37749005108
SN - 0262195348
SN - 9780262195348
T3 - Advances in Neural Information Processing Systems
BT - Advances in Neural Information Processing Systems 17 - Proceedings of the 2004 Conference, NIPS 2004
PB - Neural information processing systems foundation
Y2 - 13 December 2004 through 16 December 2004
ER -