Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi)

Zoë K. David-Gray, Howard M. Cooper, Jannie W.H. Janssen, Eviatar Nevo, Russell G. Foster

Research output: Contribution to journalArticlepeer-review

Abstract

The atrophied subcutaneous eyes of Spalax ehrenbergi (the blind mole rat) express a long wavelength sensitive (LWS) cone opsin. Our data provide strong evidence that this photopigment is spectrally tuned to enhance photon capture in the red light environment of the eye. Furthermore, novel mechanisms appear partially responsible for this sensory fine-tuning. These data support the hypothesis that the LWS opsin of Spalax acts as a functional photopigment and that it is not a 'residue' of the pre-subterranean visual system. As the eye of Spalax has only one known function, the entrainment of circadian rhythms to environmental light, the LWS photopigment is implicated in this task. These results, together with our recent findings that rod and cone photopigments are not required for murine photoentrainment, suggest that multiple photopigments (classical and novel) mediate the effects of light on the mammalian circadian system. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalFEBS Letters
Volume461
Issue number3
DOIs
StatePublished - 19 Nov 1999

Bibliographical note

Funding Information:
This work was supported by the Wellcome Trust and Biomed 2 (CT972327) to R.G.F., and HFSP (RG-68/95B), Biomed 2 (PL962327) and NATO (950334) to H.M.C.

Keywords

  • Blind mammal
  • Circadian photopigment
  • LWS photopigment
  • Spalax ehrenbergi
  • Spectral tuning

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Cell Biology

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