Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice

Britt Mellström, Asta Kastanauskaite, Shira Knafo, Paz Gonzalez, Xose M. Dopazo, Ana Ruiz-Nuño, John G.R. Jefferys, Min Zhuo, Tim V.P. Bliss, Jose R. Naranjo, Javier Defelipe

Research output: Contribution to journalArticlepeer-review


Background: Transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a Ca2+-binding protein that regulates Ca2+ homeostasis through gene regulation and protein-protein interactions. It has been shown that a dominant active form (daDREAM) is implicated in learning-related synaptic plasticity such as LTP and LTD in the hippocampus. Neuronal spines are reported to play important roles in plasticity and memory. However, the possible role of DREAM in spine plasticity has not been reported. Results: Here we show that potentiating DREAM activity, by overexpressing daDREAM, reduced dendritic basal arborization and spine density in CA1 pyramidal neurons and increased spine density in dendrites in dentate gyrus granule cells. These microanatomical changes are accompanied by significant modifications in the expression of specific genes encoding the cytoskeletal proteins Arc, Formin 1 and Gelsolin in daDREAM hippocampus. Conclusions: Our results strongly suggest that DREAM plays an important role in structural plasticity in the hippocampus.

Original languageEnglish
Article number204
JournalMolecular Brain
Issue number1
StatePublished - 29 Feb 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Mellström et al.


  • Arc
  • Calcium
  • Dendritic trees
  • Spines

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology


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