Sociodemographic factors associated with serum anti-Shigella lipopolysaccharide antibodies and shigellosis

Dani Cohen, Raphael Slepon, Manfred S. Green

Research output: Contribution to journalArticlepeer-review


The association between various sociodemographic variables and the presence of anti-Shigella sonnei lipopolysaccharide (LPS) antibodies was examined in a random sample (N = 383) of male Israeli conscripts. Of the male conscripts. 190 (49.6%) had pre-existing antibodies against S. sonnei LPS (defined as HA titres of ≥1:10 after treatment of sera with 2-mercaptoethanol). Univariate analysis revealed a significant positive association between the presence of humoral anti-S. sonnei LPS antibodies and sociodemographic variables including Eastern origin (p = 0.007), low socio-economic status (p = 0.0016), and the number of siblings (p = 0.023). When multiple logistic regression was used to control simultaneously for the effects of the other variables, ethnic origin emerged as the strongest correlate of anti-S. sonnei LPS antibodies. On the other hand, the association of the sociodemographic variables in subjects suffering from S. sonnei infection during their military service, was in the opposite direction (p<0.001 for both socioeconomic status and ethnicity). These findings suggest differences between subpopulations in acquired immunity to S. sonnei due to differences in exposure to the homologous organism prior to military service.

Original languageEnglish
Pages (from-to)546-550
Number of pages5
JournalInternational Journal of Epidemiology
Issue number2
StatePublished - Jun 1991
Externally publishedYes

Bibliographical note

Funding Information:
ACKNOWLEDGEMENT This study was supported by the United States Army Medical Research and Development Command, Grant DAMD 17-86-G-6026. We thank Drs Itzhak Ofek and Colin Block for helpful discussions.

ASJC Scopus subject areas

  • Epidemiology


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