Sleep spindles predict neural and behavioral changes in motor sequence consolidation

Marc Barakat, Julie Carrier, Karen Debas, Ovidiu Lungu, Stuart Fogel, Gilles Vandewalle, Richard D. Hoge, Pierre Bellec, Avi Karni, Leslie G. Ungerleider, Habib Benali, Julien Doyon

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to investigate the predictive function of sleep spindles in motor sequence consolidation. BOLD responses were acquired in 10 young healthy subjects who were trained on an explicitly known 5-item sequence using their left nondominant hand, scanned at 9:00 pm while performing that same task and then were retested and scanned 12 h later after a night of sleep during which polysomnographic measures were recorded. An automatic algorithm was used to detect sleep spindles and to quantify their characteristics (i.e., density, amplitude, and duration). Analyses revealed significant positive correlations between gains in performance and the amplitude of spindles. Moreover, significant increases in BOLD signal were observed in several motor-related areas, most of which were localized in the right hemisphere, particularly in the right cortico-striatal system. Such increases in BOLD signal also correlated positively with the amplitude of spindles at several derivations. Taken together, our results show that sleep spindles predict neural and behavioral changes in overnight motor sequence consolidation.

Original languageEnglish
Pages (from-to)2918-2928
Number of pages11
JournalHuman Brain Mapping
Volume34
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • Cortico-striatal system
  • EEG
  • FMRI
  • Motor sequence consolidation
  • Sleep spindles

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Anatomy

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